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Proteintech
CAMK2 Monoclonal Antibody (1E3B3), CoraLite® Plus 488
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Product Details
CL488-66843
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E3B3
Immunogen
CAMK2 fusion protein Ag4736
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MATITCTRF TEEYQLFEEL GKGAFSVVRR CVKVLAGQEY AAKIINTKKL SARDHQKLER EARICRLLKH PNIVRLHDSI SEEGHHYLIF DLVTGGELFE DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKLKG AAVKLADFGL AIEVEGEQQA WFGFAGTPGY LSPEVLRKDP YGKPVDLWAC GVILYILLVG YPPFWDEDQH RLYKQIKAGA YDFPSPEWDT VTPEAKDLIN KMLTINPSKR ITAAEALKHP WI
Target Information
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+/calmodulin (CaM) binding and autophosphorylation and has been implicated in regulation of the cell cycle and transcription. It is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha CaM kinase II; alpha-CaMKII; alternatively spliced; Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II beta subunit; Ca++/calmodulin-dependent protein kinase II delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase II alpha; Calcium, calmodulin-dependent protein kinase; Calcium, calmodulin-dependent protein kinase II; Calcium, calmodulin-dependent protein kinase, type II; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase II delta 2-subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II delta chain; calcium/calmodulin-dependent protein kinase type II gamma chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II; CaM kinase II alpha subunit; CaM kinase II beta subunit; CaM kinase II delta subunit; CaM kinase II subunit alpha; CaM kinase II subunit beta; CaM kinase II subunit delta; CaM kinase II subunit gamma; CaM-kinase II alpha chain; CaM-kinase II beta chain; CaM-kinase II delta chain; caM-kinase II gamma chain; CaMK II; CaMK-II alpha subunit; CaMK-II delta subunit; caMK-II subunit alpha; caMK-II subunit beta; caMK-II subunit delta; caMK-II subunit gamma; proline rich calmodulin-dependent protein kinase; protein kinase homolog; unnamed protein product
Gene Aliases: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CAM2; CAMK; CaMK II; CAMK-II; CAMK1; CAMK2; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMKA; CAMKB; CAMKD; CAMKG; Camki; CaMKII; CaMKIIalpha; CaMKIIbeta; CaMKIINalpha; Ck2b; KIAA0968; Kiaa4163; mKIAA0968; MRD53; MRD54; MRD59; MRT63; PK2CDD; PKCCD; R74975; RATCAMKI
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
protein binding
calmodulin binding
ATP binding
kinase activity
transferase activity
glutamate receptor binding
identical protein binding
protein homodimerization activity
metal ion binding
protein serine kinase activity
actin binding
sodium channel inhibitor activity
titin binding
ion channel binding
calcium-dependent protein serine/threonine phosphatase activity
transferase activity, transferring phosphorus-containing groups
GTPase activating protein binding
phospholipase binding
nitric-oxide synthase binding
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
response to ischemia
protein phosphorylation
calcium ion transport
JAK-STAT cascade
positive regulation of cardiac muscle cell apoptotic process
cellular response to interferon-beta
angiotensin-activated signaling pathway
positive regulation of JAK-STAT cascade
regulation of neurotransmitter secretion
regulation of neuronal synaptic plasticity
positive regulation of NF-kappaB transcription factor activity
negative regulation of hydrolase activity
positive regulation of calcium ion transport
long-term synaptic potentiation
dendritic spine development
cellular response to interferon-gamma
regulation of mitochondrial membrane permeability involved in apoptotic process
regulation of protein localization to plasma membrane
peptidyl-threonine autophosphorylation
regulation of endocannabinoid signaling pathway
regulation of neuron migration
signal transduction
nervous system development
positive regulation of neuron projection development
regulation of skeletal muscle adaptation
cell differentiation
protein autophosphorylation
regulation of long-term neuronal synaptic plasticity
regulation of synapse structural plasticity
regulation of calcium ion transport
regulation of dendritic spine development
positive regulation of dendritic spine morphogenesis
positive regulation of synapse maturation
regulation of cell growth
regulation of the force of heart contraction
regulation of membrane depolarization
regulation of transcription from RNA polymerase II promoter
regulation of heart contraction
positive regulation of cardiac muscle hypertrophy
regulation of cell communication by electrical coupling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
endoplasmic reticulum calcium ion homeostasis
relaxation of cardiac muscle
regulation of ryanodine-sensitive calcium-release channel activity
regulation of cellular localization
cellular response to calcium ion
cardiac muscle cell contraction
regulation of heart rate by cardiac conduction
regulation of cardiac muscle cell action potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of relaxation of cardiac muscle
negative regulation of sodium ion transmembrane transport
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
regulation of neuron projection development
insulin secretion
phosphorylation
peptidyl-serine phosphorylation
ionotropic glutamate receptor signaling pathway
inhibitory G-protein coupled receptor phosphorylation
regulation of synaptic transmission, cholinergic
positive regulation of phospholipase A2 activity
response to cadmium ion
cell projection morphogenesis
neuromuscular process controlling balance
activation of meiosis involved in egg activation
positive regulation of apoptotic signaling pathway
response to hypoxia
regulation of sodium ion transport
regulation of G2/M transition of mitotic cell cycle
positive regulation of smooth muscle cell migration
peptidyl-threonine phosphorylation
cellular potassium ion homeostasis
positive regulation of Rac protein signal transduction
positive regulation of smooth muscle cell proliferation
protein oligomerization
cardiac muscle contraction
cell growth involved in cardiac muscle cell development
positive regulation of ERK1 and ERK2 cascade
negative regulation of sodium ion transmembrane transporter activity
response to oxidative stress
multicellular organism development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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