Search
Proteintech
YAP1 Monoclonal Antibody (3A7A9), CoraLite® Plus 488
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL488-66900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3A7A9
Immunogen
Recombinant Protein
Conjugate
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 65 kDa Yes-associated protein; protein yorkie homolog; transcription cofactor; transcription cofactor; YAP; transcriptional co-activator; unnamed protein product; Yes associated protein 1; yes-associated protein 1; yes-associated protein 2; yes-associated protein YAP65 homolog; yes-associated protein, 65 kDa; yorkie homolog
Gene Aliases: COB1; YAP; YAP-1; YAP2; YAP65; YKI; Yorkie
UniProt ID: (Human) P46937, (Mouse) P46938, (Rat) Q2EJA0
Entrez Gene ID: (Human) 10413, (Mouse) 22601, (Rat) 363014
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
transcription corepressor activity
protein binding
proline-rich region binding
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
vasculogenesis
tissue homeostasis
morphogenesis of an epithelium
heart process
embryonic heart tube morphogenesis
cellular response to DNA damage stimulus
positive regulation of cell proliferation
regulation of gene expression
positive regulation of gene expression
negative regulation of gene expression
regulation of keratinocyte proliferation
positive regulation of keratinocyte proliferation
keratinocyte differentiation
positive regulation of cell growth
negative regulation of epithelial cell differentiation
notochord development
response to progesterone
somatic stem cell population maintenance
organ growth
hippo signaling
wound healing
regulation of cell proliferation
signal transduction in response to DNA damage
negative regulation of cell differentiation
negative regulation of fat cell differentiation
positive regulation of osteoblast differentiation
positive regulation of Notch signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of growth
positive regulation of transcription from RNA polymerase II promoter
positive regulation of organ growth
paraxial mesoderm development
lateral mesoderm development
epithelial cell proliferation
positive regulation of epithelial cell proliferation
regulation of neurogenesis
positive regulation of cardiac muscle cell proliferation
bud elongation involved in lung branching
mesenchyme development
lung epithelial cell differentiation
intestinal epithelial cell development
regulation of canonical Wnt signaling pathway
cardiac muscle tissue regeneration
canonical glycolysis
protein-containing complex assembly
interleukin-6-mediated signaling pathway
cellular response to retinoic acid
cellular response to gamma radiation
regulation of stem cell proliferation
regulation of metanephric nephron tubule epithelial cell differentiation
positive regulation of canonical Wnt signaling pathway
positive regulation of protein localization to nucleus
negative regulation of cilium assembly
positive regulation of stem cell population maintenance
negative regulation of epithelial cell apoptotic process
negative regulation of stem cell differentiation
negative regulation of extrinsic apoptotic signaling pathway
polarized epithelial cell differentiation
negative regulation of hippo signaling
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support