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Integrin Alpha 6 Monoclonal Antibody (2B12A1), CoraLite® Plus 488
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FIGURE: 1 / 1
Integrin Alpha 6 Antibody (CL488-66906) in Flow
1X10^6 A431 cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human Integrin Alpha 6 (CL488-66906, Clone:2B12A1) (red), or 0.4 µg Mouse IgG2b Isotype Control (CL488-66360-3, Clone: K11B8C4B5) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-66906
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2B12A1
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: TPNRIDLRQK TACGAPSGIC LQVKSCFEYT ANPAGYNPSI SIVGTLEAEK ERRKSGLSSR VQFRNQGSEP KYTQELTLKR QKQKVCMEET LWLQDNIRDK LRPIPITASV EIQEPSSRRR VNSLPEVLPI LNSDEPKTAH IDVHFLKEGC GDDNVCNSNL KLEYKFCTRE GNQDKFSYLP IQKGVPELVL KDQKDIALEI TVTNSPSNPR NPTK
Target Information
CDf (Integrin alpha-6, ITGA6) is the integrin alpha chain alpha 6 protein. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. Two transcript variants encoding different isoforms have been found for CDf. Functionally, integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals that affect cellular shape, mobility, and progression through the cell cycle in response to the extracellular matrix. Integrin receptors are composed of alpha and beta subunits, and form structural and functional linkages between the ECM (extra-cellular matrix) and intracellular cytoskeletal linker proteins. Signaling mediated by Intergrin/ECM interactions are also integrated with cellular responses to growth factor signaling to regulate cellular proliferation, cytoskeletal reorganization and other responses necessary for cellular survival. CDf is predominantly expressed by epithelia, and plays a critical structural role in the hemidesmosome. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD49 antigen-like family member F; CD49f; DKFZp686J01244; extracellular matrix receptor subunit; FLJ18737; Integrin alpha-6; integrin alpha6B; integrin, alpha 6; unnamed protein product; very late activation protein 6; VLA-6
Gene Aliases: CD49f; ITGA6; ITGA6A; ITGA6B; JEB6; VLA-6
UniProt ID: (Human) P23229
Entrez Gene ID: (Human) 3655
cell-substrate junction assembly
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
ectodermal cell differentiation
positive regulation of neuron projection development
positive regulation of cell migration
cell-substrate adhesion
nail development
positive regulation of apoptotic process
positive regulation of GTPase activity
skin morphogenesis
positive regulation of transcription from RNA polymerase II promoter
leukocyte migration
cell-cell adhesion
negative regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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