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Proteintech
GBP1 Monoclonal Antibody (2A10E8), CoraLite® Plus 488
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Product Details
CL488-67161
Product Specifications
Species Reactivity
Human,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2A10E8
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VHRRKLAQLE KLQDEELDPE FVQQVADFCS YIFSNSKTKT LSGGIQVNGP RLESLVLTYV NAISSGDLPC MENAVLALAQ IENSAAVQKA IAHYEQQMGQ KVQLPTESLQ ELLDLHRDSE REAIEVFIRS SFKDVDHLFQ KELAAQLEKK RDDFCKQNQE ASSDRCSGLL QVIFSPLEEE VKAGIYSKPG GYRLFVQKLQ DLKKKYYEEP RKGIQAEEIL QTYLKSKESM TDAILQTDQT LTEKEKEIEV ERVKAESAQA SAKMLQEMQR KNEQMMEQKE RSYQEHLKQL TEKMENDRVQ LLKEQERTLA LKLQEQEQLL KEGFQKESRI MKNEIQDLQT KMRRRKACTI S
Target Information
GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules. GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a. Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement. Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells. As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GBP-1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; guanylate binding protein 1, interferon-inducible; guanylate binding protein 1, interferon-inducible, 67kDa; Guanylate-binding protein 1; huGBP-1; Interferon-induced guanylate-binding protein 1; unnamed protein product
Gene Aliases: GBP1; hGBP1
UniProt ID: (Human) P32455
Entrez Gene ID: (Pig) 100151938, (Human) 2633, (Rat) 304266
nucleotide binding
lipopolysaccharide binding
actin binding
GTPase activity
obsolete small monomeric GTPase activity
guanosine-diphosphatase activity
protein binding
GTP binding
hydrolase activity
GDP binding
enzyme binding
cytokine binding
spectrin binding
identical protein binding
protein homodimerization activity
Hsp90 protein binding
GMP binding
heterotrimeric G-protein
immune system process
negative regulation of interleukin-2 production
defense response to bacterium
defense response to protozoan
innate immune response
regulation of calcium-mediated signaling
negative regulation of T cell receptor signaling pathway
protein maturation
defense response to virus
cytolysis in other organism
negative regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
protein localization to vacuole
positive regulation of pyroptotic inflammatory response
non-canonical inflammasome complex assembly
negative regulation of substrate adhesion-dependent cell spreading
regulation of protein localization to plasma membrane
negative regulation of protein localization to plasma membrane
metabolic process
cellular response to interferon-beta
adhesion of symbiont to host
defense response to Gram-positive bacterium
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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