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Proteintech
CUL2 Monoclonal Antibody (1A6G9), CoraLite® Plus 488
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Product Details
CL488-67175
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A6G9
Immunogen
CUL2 fusion protein Ag28654
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: ESVLEVHGK FVQLINTVLN GDQHFMSALD KALTSVVNYR EPKSVCKAPE LLAKYCDNLL KKSAKGMTEN EVEDRLTSFI TVFKYIDDKD VFQKFYARML AKRLIHGLSM SMDSEEAMIN KLKQACGYEF TSKLHRMYTD MSVSADLNNK FNNFIKNQDT VIDLGISFQI YVLQAGAWPL TQAPSSTFAI PQELEKSVQM FELFYSQHFS GRKLTWLHYL CTGEVKMNYL GKPYVAMVTT YQMAVLLAFN NSETVSYKEL QDSTQMNEKE LTKTIKSLLD VKMINHDSEK EDIDAESSFS LNMNFSSKRT KFKITTSMQK DTPQEMEQTR SAVDEDRKMY LQAAIVRIMK ARKVLRHNAL IQEVISQSRA RFNPSISMIK KCIEVLIDKQ YIERSQASAD EYSYVA
Target Information
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CUL-2; Cullin family member; Cdc53 homolog; Cullin-2; MGC131970; OTTHUMP00000019437; testis secretory sperm-binding protein Li 238E; unnamed protein product
Gene Aliases: CUL2
UniProt ID: (Human) Q13617
Entrez Gene ID: (Human) 8453, (Rat) 361258
G1/S transition of mitotic cell cycle
ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
protein ubiquitination
protein catabolic process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
intrinsic apoptotic signaling pathway
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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