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Proteintech
MRP1 Monoclonal Antibody (1G4A2), CoraLite® Plus 488
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Product Details
CL488-67228
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G4A2
Immunogen
MRP1 fusion protein Ag27048
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SSYSGDISR HHNSTAELQK AEAKKEETWK LMEADKAQTG QVKLSVYWDY MKAIGLFISF LSIFLFMCNH VSALASNYWL SLWTDDPIVN GTQEHTKVRL SVYGALGIS
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette sub-family C member 1; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25&26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; DKFZp686N04233; DKFZp781G125; glutathione S-conjugate export pump; Glutathione-S-conjugate-translocating ATPase ABCC1; leuk; Leukotriene C(4) transporter; LTC4 transporter; Multidrug resistance-associated protein 1
Gene Aliases: ABC29; ABCC; ABCC1; DFNA77; GS-X; MRP; MRP1
UniProt ID: (Human) P33527
Entrez Gene ID: (Human) 4363
nucleotide binding
ATP binding
xenobiotic-transporting ATPase activity
cobalamin-transporting ATPase activity
glutathione S-conjugate-exporting ATPase activity
efflux transmembrane transporter activity
hydrolase activity
ATPase activity
transmembrane transporter activity
lipid-transporting ATPase activity
glutathione transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
anion transmembrane-transporting ATPase activity
sphingolipid transporter activity
carboxylic acid transmembrane transporter activity
ABC-type transporter activity
leukotriene metabolic process
xenobiotic metabolic process
lipid transport
response to xenobiotic stimulus
cobalamin transport
sphingolipid biosynthetic process
cellular response to oxidative stress
glutathione transmembrane transport
heme catabolic process
xenobiotic transport
phospholipid translocation
carboxylic acid transport
positive regulation of inflammatory response
transmembrane transport
cell chemotaxis
transepithelial transport
cyclic nucleotide transport
leukotriene transport
anion transmembrane transport
sphingolipid translocation
export across plasma membrane
transport across blood-brain barrier
cellular response to beta-amyloid
carboxylic acid transmembrane transport
drug transport across blood-brain barrier
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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