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Proteintech
RGS14 Monoclonal Antibody (1C1B2), CoraLite® Plus 488
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Product Details
CL488-67394
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C1B2
Immunogen
RGS14 fusion protein Ag9477
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: KSLPLGVEE LGQLPPVEGP GGRPLRKSFR RELGGTANAA LRRESQGSLN SSASLDLGFL AFVSSKSESH RKSLGSTEGE SESRPGKYCC VYLPDGTASL ALARPGLTIR DMLAGICEKR GLSLPDIKVY LVGNEQALVL DQDCTVLADQ EVRLENRITF ELELTALERV VRISAKPTKR LQEALQPILE KHGLSPLEVV LHRPGEKQPL DLGKLVSSVA AQRLVLDTLP GVKISKARDK SPCRSQGCPP RTQDKATHPP PASPSSLVKV PSSATGKRQT CDIEGLVELL NRVQSSGAHD QRGLLRKEDL VLPEFLQLPA QGPSSEETPP QTKSAAQPIG GSLNSTTDSA L
Target Information
RGS14 is a member of the regulator of G-protein signaling family which contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. RGS14 attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. The resulting hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of RGS14 have been observed but have not been thoroughly characterized. Further, RGS14 acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism; plays a role in cell division; is required for the nerve growth factor (NGF)-mediated neurite outgrowth, and is involved in stress resistance. RGS14 protein may also be involved in visual memory processing capacity and hippocampal-based learning and memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: rap1/rap2 interacting protein; RAP1/RAP2-interacting protein; Regulator of G-protein signaling 14; RGS14; RGSE; RPIP1; unnamed protein product
Gene Aliases: RGS14; RPIP1
UniProt ID: (Human) O43566, (Mouse) P97492, (Rat) O08773
Entrez Gene ID: (Human) 10636, (Mouse) 51791, (Rat) 114705
G-protein alpha-subunit binding
GTPase activity
GDP-dissociation inhibitor activity
GTPase activator activity
protein binding
microtubule binding
protein kinase binding
receptor signaling complex scaffold activity
GTPase regulator activity
GTPase activating protein binding
receptor signaling protein activity
nucleocytoplasmic transport
response to oxidative stress
cell cycle
spindle organization
chromosome segregation
mitotic nuclear division
signal transduction
G-protein coupled receptor signaling pathway
multicellular organism development
learning
long-term memory
regulation of G-protein coupled receptor protein signaling pathway
visual learning
negative regulation of signal transduction
zygote asymmetric cell division
negative regulation of synaptic plasticity
intracellular signal transduction
termination of G-protein coupled receptor signaling pathway
negative regulation of MAP kinase activity
positive regulation of GTPase activity
regulation of DNA-templated transcription in response to stress
platelet-derived growth factor receptor signaling pathway
positive regulation of neurogenesis
cell division
long-term synaptic potentiation
negative regulation of ERK1 and ERK2 cascade
mitotic cell cycle
negative regulation of G-protein coupled receptor protein signaling pathway
modulation of synaptic transmission
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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