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EXOSC9 Monoclonal Antibody (3F4G1), CoraLite® Plus 488
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FIGURE: 1 / 1
EXOSC9 Antibody (CL488-67636) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human EXOSC9 (CL488-67636, Clone:3F4G1) (red), or 0.4 µg Mouse IgG2a Isotype Control (CL488-66360-2, Clone: K11A1B2A2) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL488-67636
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
3F4G1
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MKETPLSNCE RRFLLRAIEE KKRLDGRQTY DYRNIRISFG TDYGCCIVEL GKTRVLGQVS CELVSPKLNR ATEGILFFNL ELSQMAAPAF EPGRQSDLLV KLNRLMERCL RNSKCIDTES LCVVAGEKVW QIRVDLHLLN HDGNIIDAAS IAAIVALCHF RRPDVSVQGD EVTLYTPEER DPVPLSIHHM PICVSFAFFQ QGAYLLVDPN EREERVMDGL LVIAMNKHRE ICTIQSSGGI MLLKDQVLRC SKIAGVKVAE ITELILKALE NDQKVRKEGG KFGFAESIAN QRITAFKMEK APIDTSDVEE KAEEIIAEAE PPSEVVSTPV LWTPGTAQIG EGVENSWGDL E
Target Information
This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Autoantigen PM/Scl 1; Exosome complex component RRP45; exosome complex exonuclease RRP45; Exosome component 9; P75 polymyositis-scleroderma overlap syndrome associated autoantigen; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl-75; PMSCL autoantigen, 75kD; Polymyositis/scleroderma autoantigen 1; polymyositis/scleroderma autoantigen 1, 75kDa; Polymyositis/scleroderma autoantigen 75 kDa; unnamed protein product
Gene Aliases: EXOSC9; p5; p6; PCH1D; PM/Scl-75; PMSCL1; RRP45; Rrp45p
UniProt ID: (Human) Q06265, (Mouse) Q9JHI7, (Rat) Q4QR75
Entrez Gene ID: (Human) 5393, (Mouse) 50911, (Rat) 294975
3'-5'-exoribonuclease activity
RNA binding
exoribonuclease activity
protein binding
mRNA 3'-UTR AU-rich region binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
nuclease activity
exonuclease activity
hydrolase activity
AU-rich element binding
poly(A) RNA binding
RNA metabolism protein
exoribonuclease
nucleic acid metabolism protein
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
nuclear-transcribed mRNA catabolic process
rRNA processing
RNA processing
RNA catabolic process
mRNA catabolic process
immune response
rRNA catabolic process
positive regulation of cell growth
U1 snRNA 3'-end processing
U4 snRNA 3'-end processing
U5 snRNA 3'-end processing
positive regulation of transcription from RNA polymerase II promoter
nuclear mRNA surveillance
nuclear polyadenylation-dependent rRNA catabolic process
nuclear polyadenylation-dependent tRNA catabolic process
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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