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Proteintech
CYR61 Monoclonal Antibody (2E11F11), CoraLite® Plus 488
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Product Details
CL488-67656
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2E11F11
Immunogen
CYR61 fusion protein Ag25129
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: EDSIKDPME DQDGLLGKEL GFDASEVELT RNNELIAVGK GSSLKRLPVF GMEPRILYNP LQGQKCIVQT TSWSQC
Target Information
CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCN family member 1; Cellular communication network factor 1; CYR61; cysteine rich angiogenic inducer 61; Cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, anigogenic inducer, 61; IBP-10; IGF-binding protein 10; IGFBP-10; Insulin-like growth factor-binding protein 10; Protein CYR61; Protein GIG1; tumor RMS cell line RD specific product; unnamed protein product
Gene Aliases: CCN1; CYR61; GIG1; IGFBP10
UniProt ID: (Human) O00622
Entrez Gene ID: (Human) 3491
osteoblast differentiation
intussusceptive angiogenesis
atrioventricular valve morphogenesis
apoptotic process involved in heart morphogenesis
ventricular septum development
apoptotic process
chemotaxis
cell adhesion
signal transduction
integrin-mediated signaling pathway
positive regulation of biosynthetic process
regulation of macromolecule biosynthetic process
positive regulation of cell-substrate adhesion
extracellular matrix organization
positive regulation of cell migration
positive regulation of bone mineralization
positive regulation of BMP signaling pathway
positive regulation of osteoblast proliferation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of cell differentiation
positive regulation of osteoblast differentiation
positive regulation of ossification
positive regulation of transcription from RNA polymerase II promoter
positive regulation of developmental process
atrial septum morphogenesis
chondroblast differentiation
chorio-allantoic fusion
labyrinthine layer blood vessel development
positive regulation of cartilage development
regulation of ERK1 and ERK2 cascade
reactive oxygen species metabolic process
cell-cell adhesion
regulation of multicellular organismal development
positive regulation of ceramide biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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