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Proteintech
DVL1 Monoclonal Antibody (1A2A5), CoraLite® Plus 488
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL488-67672
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A2A5
Immunogen
Recombinant protein
Conjugate
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LGQGYPYQYP GPPPCFPPAY QDPGFSYGSG STGSQQSEGS KSSGSTRSSR RAPGREKERR AAGAGGSGSE SDHTAPSGVG SSWRERPAGQ LSRGSSPRSQ ASATAPGLPP PHPTTKAYTV VGGPPGGPPV RELA
Target Information
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. TheSchwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2Ahave been mapped to the same region as DVL1. The phenotypes ofthese diseases may be consistent with defects which might beexpected from aberrant expression of a DVL gene during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1; dishevelled-1; Dishevelled-1-like; DSH homolog 1; DSH homolog 1-like; MGC54245; RP5-890O3.5; similar to Drosophila dishevelled segment polarity gene, GenBank Accession Number U02491; unnamed protein product
Gene Aliases: DRS2; DVL; dvl-1; DVL1L1; mKIAA4029
UniProt ID: (Human) O14640, (Rat) Q9WVB9, (Mouse) P51141
Entrez Gene ID: (Human) 1855, (Rat) 83721, (Mouse) 13542
regulation of protein phosphorylation
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
heart looping
outflow tract morphogenesis
regulation of transcription, DNA-templated
neurotransmitter secretion
axonogenesis
axon guidance
neuromuscular junction development
positive regulation of neuron projection development
Wnt signaling pathway
neural tube development
convergent extension involved in neural plate elongation
cytoplasmic microtubule organization
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of protein localization
protein localization to nucleus
social behavior
protein localization to microtubule
intracellular signal transduction
receptor clustering
positive regulation of transcription from RNA polymerase II promoter
collateral sprouting
axon extension
dendrite morphogenesis
synapse organization
protein stabilization
convergent extension involved in organogenesis
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
prepulse inhibition
dendritic spine morphogenesis
skeletal muscle acetylcholine-gated channel clustering
cochlea morphogenesis
presynapse assembly
postsynapse organization
regulation of postsynapse organization
positive regulation of neuron projection arborization
regulation of synaptic vesicle exocytosis
positive regulation of excitatory postsynaptic potential
non-canonical Wnt signaling pathway
positive regulation of protein localization to presynapse
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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