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Proteintech
ATG4B Monoclonal Antibody (1G5A7), CoraLite® Plus 488
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Product Details
CL488-67727
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1G5A7
Immunogen
ATG4B fusion protein Ag30510
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MDAATLTYD TLRFAEFEDF PETSEPVWIL GRKYSIFTEK DEILSDVASR LWFTYRKNFP AIGGTGPTSD TGWGCMLRCG QMIFAQALVC RHLGRDWRWT QRKRQPDSYF SVLNAFIDRK DSYYSIHQIA QMGVGEGKSI GQWYGPNTVA QVLKKLAVFD TWSSLAVHIA MDNTVVMEEI RRLCRTSVPC AGATAFPADS DRHCNGFPAG AEVTNRPSPW RPLVLLIPLR LGLTDINEAY VETLKHCFMM PQSLGVIGGK PNSAHYFIGY VGEELIYLDP HTTQPAVEPT DGCFIPDESF HCQHPPCRMS IAELDPSIAV GFFCKTEDDF NDWCQQVKKL SLLGGALPMF ELVEQQPSHL ACPDVLNLSL DSSDVERLER FFDSEDEDFE ILSL
Target Information
Cysteine protease ATG4b is an enzyme which is coded by ATG4b gene. Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and protein. ATG4b is a deubiquitin-like protease that plays dual roles in the core machinery of autophagy. ATG4b, cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. ATG4b is mainly expressed in the skeletal muscle, brain, heart, liver and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APG4 (ATG4) autophagy-related homolog B; APG4 autophagy 4 homolog B; ATG4 autophagy related 4 homolog B; AUT-like 1 cysteine; AUT-like 1 cysteine endopeptidase; AUT-like 1, cysteine endopeptidase; autophagin 1; Autophagin-1; autophagy related 4 homolog B; autophagy-related 4B; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; Cysteine protease ATG4B; cysteine protease involved in autophagy APG4-B; hAPG4B; HsAPG4B; MmAPG4B; unnamed protein product
Gene Aliases: 2510009N07Rik; APG4B; ATG4B; Atg4bl; AUTL1; AW048066; HsAPG4B; KIAA0943
UniProt ID: (Human) Q9Y4P1, (Mouse) Q8BGE6, (Rat) A0A0G2QC33
Entrez Gene ID: (Human) 23192, (Mouse) 66615, (Rat) 316640
autophagosome assembly
mitophagy
proteolysis
autophagy
protein transport
macroautophagy
lysosomal microautophagy
protein processing
otolith mineralization completed early in development
protein localization to pre-autophagosomal structure
piecemeal microautophagy of nucleus
aggrephagy
protein delipidation
mitophagy
C-terminal protein lipidation
protein targeting to membrane
transport
cellular response to nitrogen starvation
positive regulation of autophagy
nucleophagy
positive regulation of protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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