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ITCH Monoclonal Antibody (2E3G9), CoraLite® Plus 488

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ITCH Monoclonal Antibody (2E3G9), CoraLite® Plus 488

Product Details

CL488-67757

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.4 µg/1x10^6 cell suspension
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

2E3G9

Immunogen

Recombinant protein
View immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: TLFEDSFQQI MSFSPQDLRR RLWVIFPGEE GLDYGGVARE WFFLLSHEVL NPMYCLFEYA GKDNYCLQIN PASYINPDHL KYFRFIGRFI AMALFHGKFI DTGFSLPFYK RILNKPVGLK DLESIDPEFY NSLIWVKENN IEECDLEMYF SVDKEILGEI KSHDLKPNGG NILVTEENKE EYIRMVAEWR LSRGVEEQTQ AFFEGFNEIL PQQYLQYFDA KELEVLLCGM QEIDLNDWQR HAIYRHYART SKQIMWFWQF VKEIDNEKRM RLLQFVTGTC RLPVGGFADL MGSNGPQKFC IEKVGKENWL PRSHTCFNRL DLPPYKSYEQ LKEKLLFAIE ETEGFGQE

Target Information

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AIP4; atrophin-1 interacting protein 4; Atrophin-1-interacting protein 4; dJ468O1.1; E3 ubiquitin-protein ligase Itchy; E3 ubiquitin-protein ligase Itchy homolog; HECT-type E3 ubiquitin transferase Itchy homolog; Itch; itch E3 ubiquitin ligase; itchy E3 ubiquitin protein ligase homolog; itchy, E3 ubiquitin protein ligase; NAPP1; Nedd 4 like ubiquitin protein ligase; NFE2-associated polypeptide 1; unnamed protein product

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Gene Aliases: 6720481N21Rik; 8030492O04Rik; A130065M08; ADMFD; AIF4; AIP4; C230047C07Rik; ITCH; NAPP1

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UniProt ID: (Human) Q96J02, (Mouse) Q8C863

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Entrez Gene ID: (Human) 83737, (Mouse) 16396, (Rat) 311567

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Function(s)
ubiquitin-protein transferase activity protein binding transferase activity ligase activity ubiquitin-like protein transferase activity ubiquitin-ubiquitin ligase activity ribonucleoprotein complex binding ubiquitin-like protein ligase binding CXCR chemokine receptor binding ubiquitin protein ligase activity arrestin family protein binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity ubiquitin-protein ligase
Process(es)
protein polyubiquitination regulation of cell growth immune system process positive regulation of T cell anergy negative regulation of immune system process positive regulation of immune system process cytoplasmic pattern recognition receptor signaling pathway T cell anergy ubiquitin-dependent protein catabolic process protein monoubiquitination apoptotic process inflammatory response response to oxidative stress positive regulation of catabolic process regulation of gene expression positive regulation of macromolecule metabolic process protein ubiquitination protein catabolic process receptor internalization negative regulation of type I interferon production protein K29-linked ubiquitination CD4-positive, alpha-beta T cell proliferation nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway CXCL12-activated CXCR4 signaling pathway negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process innate immune response positive regulation of protein catabolic process negative regulation of JNK cascade viral entry into host cell negative regulation of defense response to virus negative regulation of multicellular organismal process defense response to virus protein autoubiquitination regulation of necroptotic process protein K63-linked ubiquitination protein K48-linked ubiquitination regulation of protein deubiquitination protein branched polyubiquitination regulation of hematopoietic stem cell differentiation negative regulation of intracellular signal transduction negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of receptor catabolic process negative regulation of NF-kappaB transcription factor activity protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of alpha-beta T cell proliferation
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