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Proteintech
AHR Monoclonal Antibody (2D1F9), CoraLite® Plus 488
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FIGURE: 1 / 1
AHR Antibody (CL488-67785) in Flow
1X10^6 HepG2 cells were intracellularly stained with 0.8 µg CoraLite® Plus 488 Anti-Human AHR (CL488-67785, Clone:2D1F9) (red), or 0.8 µg Mouse IgG2b Isotype Control (CL488-66360-3, Clone: K11B8C4B5) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-67785
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2D1F9
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PIPAEGIKSN PSKRHRDRLN TELDRLASLL PFPQDVINKL DKLSVLRLSV SYLRAKSFFD VALKSSPTER NGGQDNCRAA NFREGLNLQE GEFLLQALNG FVLVVTTDAL VFYASSTIQD YLGFQQSDVI HQSVYELIHT EDRAEFQRQL HWALNPSQCT ESGQGIEEAT GLPQTVVCYN PDQIPPENSP LMERCFICRL RCLLDNSSGF LAMNFQGKLK YLHGQKKKGK DGSILPPQLA LFAIATPLQP PSILEIRTKN FIFRTKHKLD FTPIGC
Target Information
AHR (Ah Receptor) belongs to a family of proteins comprised of its dimerization partner ARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM. AHR contains an N-terminal sequence of approximately 200 amino acids termed the PAS domain. AHR, found in a variety of tissues, binds to a specific DNA enhancer sequence and initiates transcription of the mRNA for the cytochrome P-450 (CYPIA1) gene. The gene for AHR encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. AHR has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450, and its ligands included a variety of aromatic hydrocarbons. AHR is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for AHR. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form, and this transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ah receptor; AH-receptor; aromatic hydrocarbon receptor; Aryl hydrocarbon receptor; bHLHe76; Class E basic helix-loop-helix protein 76
Gene Aliases: AHR; BHLHE76; FVH3; RP85
UniProt ID: (Human) P35869
Entrez Gene ID: (Human) 196, (Rat) 25690
transcription regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
TFIID-class transcription factor binding
transcription coactivator binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
TBP-class protein binding
protein homodimerization activity
protein heterodimerization activity
protein dimerization activity
Hsp90 protein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
E-box binding
sequence-specific double-stranded DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
signal transducer activity
aryl hydrocarbon receptor activity
transcription factor binding
enhancer binding
sequence-specific DNA binding
transcription regulatory region DNA binding
basic helix-loop-helix transcription factor
blood vessel development
regulation of adaptive immune response
negative regulation of T cell mediated immune response to tumor cell
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
xenobiotic metabolic process
apoptotic process
response to xenobiotic stimulus
response to toxic substance
regulation of gene expression
intracellular receptor signaling pathway
regulation of B cell proliferation
circadian regulation of gene expression
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
negative regulation of inflammatory response
intestinal epithelial structure maintenance
cellular response to molecule of bacterial origin
cellular response to cAMP
cellular response to forskolin
cellular response to 2,3,7,8-tetrachlorodibenzodioxine
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
ovarian follicle development
patterning of blood vessels
B cell homeostasis
liver development
blood vessel remodeling
lymphocyte homeostasis
immune system process
negative regulation of systemic arterial blood pressure
cardiac left ventricle morphogenesis
circumferential growth involved in left ventricle morphogenesis
transcription from RNA polymerase II promoter
blood circulation
response to organic cyclic compound
prostate gland development
response to estradiol
embryonic hemopoiesis
post-embryonic hemopoiesis
camera-type eye development
T cell homeostasis
positive regulation of cell size
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
negative regulation of vasoconstriction
positive regulation of growth
blood vessel morphogenesis
spleen development
reproductive structure development
gland development
smooth muscle tissue development
regulation of blood vessel size
negative regulation of necrotic cell death
venous blood vessel development
kidney morphogenesis
common bile duct development
cellular response to glucocorticoid stimulus
glomerulus morphogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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