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GSTM1 Monoclonal Antibody (3C5C2), CoraLite® Plus 488
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FIGURE: 1 / 1
GSTM1 Antibody (CL488-67862) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human GSTM1 (CL488-67862, Clone:3C5C2) (red), or 0.4 µg Mouse IgG2b Isotype Control (CL488-66360-3, Clone: K11B8C4B5) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-67862
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3C5C2
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MPMILGYWDI RGLAHAIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL PYLIDGAHKI TQSNAILCYI ARKHNLCGET EEEKIRVDIL ENQTMDNHMQ LGMICYNPEF EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG NKGLEKISAY MKSSRFLPRP VFSKMAVWGN K
Target Information
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13. 3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glutathione S-alkyltransferase; glutathione S-aralkyltransferase; glutathione S-aryltransferase; Glutathione S-transferase 2; Glutathione S-transferase GT8.7; glutathione S-transferase M1; Glutathione S-transferase Mu 1; Glutathione S-transferase Yb-1; glutathione S-transferase Yb-1 subunit; glutathione S-transferases CL2; glutathione-S-transferase mu type 1 (Yb1); glutathione-S-transferase, mu 1; glutathione-S-transferase, mu type 1 (Yb1); GST 1-1; GST 3-3; GST class-mu; GST class-mu 1; GST HB subunit 4; GST Yb1; GST-CL2; GSTM1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; HB subunit 4; pmGT10; S-(hydroxyalkyl)glutathione lyase; unnamed protein product
Gene Aliases: GST1; GSTA3; Gstb-1; Gstb1; GSTM1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GSTM2; GTH4; GTM1; H-B; MU; MU-1
UniProt ID: (Human) P09488, (Chicken) P20136, (Mouse) Q58ET5, (Rat) P04905
Entrez Gene ID: (Human) 2944, (Chicken) 395976, (Mouse) 14862, (Rat) 24423
lipid metabolic process
prostaglandin metabolic process
glutathione metabolic process
nitrobenzene metabolic process
xenobiotic catabolic process
hepoxilin biosynthetic process
cellular detoxification of nitrogen compound
glutathione derivative biosynthetic process
long-chain fatty acid biosynthetic process
metabolic process
cellular response to drug
sensory perception of smell
response to metal ion
response to lithium ion
response to lead ion
response to drug
response to amino acid
response to ethanol
response to antibiotic
response to axon injury
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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