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Proteintech
PXR Monoclonal Antibody (1G3A7), CoraLite® Plus 488
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Product Details
CL488-67912
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G3A7
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MTCEGCKGFF RRAMKRNARL RCPFRKGACE ITRKTRRQCQ ACRLRKCLES GMKKEMIMSD EAVEERRALI KRKKSERTGT QPLGVQGLTE EQRMMIRELM DAQMKTFDTT FSHFKNFRPG VLSSGCELPE SLQAPSREEA AKWSQVRKDL CSLKVSLQLR GEDGSVWNYK PPADSGGKEI FSLLPHMADM STYMFKGIIS FAKVISYFRD LPIEDQISLL KGAAFELCQL RFNTVFNAET GTWECGRLSY CLEDTAGGFQ QLLLEPMLKF HYMLKKLQLH EEEYVLMQAI SLFSPDRPGV LQHRVVDQLQ EQFAITLKSY IECNRPQPAH RFLFLKIMAM LTELRSINAQ HTQRLLRIQD IHPFATPLMQ ELFGITGS
Target Information
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; ONR 1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR 1; PAR 2; PAR q; Pregnane X receptor; pregnane X receptor (nuclear receptor sub family 1, group I, member 2); putative new variant; Steroid and xenobiotic receptor; SXR; unnamed protein product
Gene Aliases: BXR; mPXR; NR1I2; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; PXR.1; PXR.2; PXR1; SAR; SXR
UniProt ID: (Human) O75469, (Rat) Q9R1A7, (Mouse) O54915
Entrez Gene ID: (Human) 8856, (Rat) 84385, (Mouse) 18171
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
ligand-dependent nuclear receptor binding
sequence-specific DNA binding
metal ion binding
sequence-specific double-stranded DNA binding
steroid hormone receptor activity
drug binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
xenobiotic metabolic process
signal transduction
steroid metabolic process
positive regulation of gene expression
cell differentiation
intracellular receptor signaling pathway
xenobiotic catabolic process
xenobiotic transport
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
intestinal epithelial structure maintenance
cellular response to molecule of bacterial origin
transcription, DNA-templated
exogenous drug catabolic process
steroid hormone mediated signaling pathway
drug export
transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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