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Proteintech
DDX1 Monoclonal Antibody (1G10G4), CoraLite® Plus 488
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Product Details
CL488-67991
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G10G4
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: IPQVTSDGKR LQVIVCSATL HSFDVKKLSE KIMHFPTWVD LKGEDSVPDT VHHVVVPVNP KTDRLWERLG KSHIRTDDVH AKDNTRPGAN SPEMWSEAIK ILKGEYAVRA IKEHKMDQAI IFCRTKIDCD NLEQYFIQQG GGPDKKGHQF SCVCLHGDRK PHERKQNLER FKKGDVRFLI CTDVAARGID IHGVPYVINV TLPDEKQNYV HRIGRVGRAE RMGLAISLVA TEKEKVWYHV CSSRGKGCYN TRLKEDGGCT IWYNEMQLLS EIEEHLNCTI SQVEPDIKVP VDEFDGKVTY GQKRAAGGGS YKGHVDILAP TVQELAALEK EAQTSFLHLG YLPNQLFRTF
Target Information
DDX1 (ATP-dependent RNA helicase DDX1) acts as an ATP-dependent RNA helicase. It is able to unwind both RNA-RNA and RNA-DNA duplexes. DDX1 possesses 5' single-stranded RNA overhand nuclease activity and ATPase activity on various RNA, but not DNA polynucleotides. DDX1, together with RELA, acts as a coactivator to enhance NF-kappa-b-mediated transcriptional activation. It also acts as a positive transcriptional regulator of cyclin CCND2 expression. It binds to the cyclin CCND2 promoter region. DDX1 is a component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double stranded RNA and plays a role in activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Asp-Glu-Ala-Asp box; ATP-dependent RNA helicase DDX1; DBP-RB; DEAD (Asp-Glu-Ala-Asp) box helicase 1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box polypeptide 1; DEAD box protein 1; DEAD box protein retinoblastoma; DEAD box-1; DEAD-box RNA helicase DDX1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1; DEAD/H-box helicase 1; unnamed protein product
Gene Aliases: AA409185; DBP-RB; DDX1; UKVH5d
UniProt ID: (Human) Q92499, (Rat) Q641Y8, (Mouse) Q91VR5
Entrez Gene ID: (Human) 1653, (Rat) 84474, (Mouse) 104721
nucleotide binding
nucleic acid binding
DNA binding
chromatin binding
transcription cofactor activity
RNA binding
RNA helicase activity
double-stranded RNA binding
helicase activity
nuclease activity
exonuclease activity
protein binding
ATP binding
poly(A) binding
hydrolase activity
ATPase activity
DNA/RNA helicase activity
ATP-dependent helicase activity
poly(A) RNA binding
ATP-dependent RNA helicase activity
spliceosomal complex assembly
immune system process
positive regulation of myeloid dendritic cell cytokine production
double-strand break repair
tRNA splicing, via endonucleolytic cleavage and ligation
mRNA processing
regulation of translational initiation
tRNA processing
response to virus
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
innate immune response
defense response to virus
protein localization to cytoplasmic stress granule
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
DNA duplex unwinding
nucleic acid phosphodiester bond hydrolysis
RNA secondary structure unwinding
regulation of nucleic acid-templated transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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