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SNCB Monoclonal Antibody (2B10E10), CoraLite® Plus 488
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FIGURE: 1 / 1
SNCB Antibody (CL488-68046) in Flow
1X10^6 SH-SY5Y cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human SNCB (CL488-68046, Clone:2B10E10) (red), or 0.4 µg Control Antibody. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-68046
Product Specifications
Species Reactivity
Rat,
Chicken,
Human,
Mouse,
Pig,
Rabbit
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2B10E10
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
Target Information
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-synuclein; I(2)-synuclein; Phosphoneuroprotein 14; PNP 14; SNCB
Gene Aliases: AI838531; betaSYN; SNCB
UniProt ID: (Human) Q16143, (Mouse) Q91ZZ3, (Rat) Q63754
Entrez Gene ID: (Rabbit) 100354265, (Human) 6620, (Pig) 100127169, (Chicken) 395391, (Mouse) 104069, (Rat) 113893
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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