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Proteintech
PRAME Monoclonal Antibody (1E9G9), CoraLite® Plus 488
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Product Details
CL488-68097
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1E9G9
Immunogen
PRAME fusion protein Ag1906
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MERRRLWGS IQSRYISMSV WTSPRRLVEL AGQSLLKDEA LAIAALELLP RELFPPLFMA AFDGRHSQTL KAMVQAWPFT CLPLGVLMKG QHLHLETFKA VLDGLDVLLA QEVRPRRWKL QVLDLRKNSH QDFWTVWSGN RASLYSFPEP EAAQPMTKKR KVDGLSTEAE QPFIPVEVLV DLFLKEGACD ELFSYLIEKV KRKKNVLRLC CKKLKIFAMP MQDIKMILKM VQLDSIEDLE VTCTWKLPTL AKFSPYLGQM INLRRLLLSH IHASSYISPE KEEQYIAQFT SQFLSLQCLQ ALYVDSLFFL RGRLDQLLRH VMNPLETLSI TNCRLSEGDV MHLSQSPSVS QLSVLSLSGV MLTDVSPEPL QALLERASAT LQDLVFDECG ITDDQLLALL PSLSHCSQLT TLSFYGNSIS ISALQSLLQH LIGLSNLTHV LYPVPLESYE DIHGTLHLER LAYLHARLRE LLCELGRPSM VWLSANPCPH CGDRTFYDPE PILCPCFMPN
Target Information
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cancer/testis antigen 130; encodes tumor antigen recognized by cytolytic T lymphocytes; Melanoma antigen preferentially expressed in tumors; OIP-4; Opa-interacting protein 4; Opa-interacting protein OIP4; PRAME; preferentially expressed antigen in melanoma; Preferentially expressed antigen of melanoma; similar to PRAME; unnamed protein product
Gene Aliases: 4930534P07Rik; CT130; MAPE; OIP-4; OIP4; PRAME
UniProt ID: (Human) P78395
Entrez Gene ID: (Human) 23532, (Rat) 680000, (Mouse) 75829
protein polyubiquitination
apoptotic process
positive regulation of cell proliferation
protein ubiquitination
cell differentiation
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of cell differentiation
negative regulation of transcription, DNA-templated
negative regulation of retinoic acid receptor signaling pathway
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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