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TOLLIP Monoclonal Antibody (1B3C4), CoraLite® Plus 488
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FIGURE: 1 / 1
TOLLIP Antibody (CL488-68170) in Flow
1x10^6 Jurkat cells were intracellularly stained with 0.8 µg CoraLite® Plus 488 Anti-Human TOLLIP (CL488-68170, Clone: 1B3C4) (red), or 0.8 µg CoraLite® Plus 488 Mouse IgG1 Isotype Control (MOPC-21) (CL488-65124, Clone: MOPC-21) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-68170
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B3C4
Immunogen
TOLLIP fusion protein Ag32731
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MATTVSTQR GPVYIGELPQ DFLRITPTQQ QRQVQLDAQA AQQLQYGGAV GTVGRLNITV VQAKLAKNYG MTRMDPYCRL RLGYAVYETP TAHNGAKNPR WNKVIHCTVP PGVDSFYLEI FDERAFSMDD RIAWTHITIP ESLRQGKVED KWYSLSGRQG DDKEGMINLV MSYALLPAAM VMPPQPVVLM PTVYQQGVGY VPITGMPAVC SPGMVPVALP PAAVNAQPRC SEEDLKAIQD MFPNMDQEVI RSVLEAQRGN KDAAINSLLQ MGEEP
Target Information
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adapter protein; FLJ33531; Toll-interacting protein; TOLLIP; tollip {ECO:0000312|EMBL:AAI33068.1}; unnamed protein product
Gene Aliases: 4930403G24Rik; 4931428G15Rik; IL-1RAcPIP; TOLLIP
UniProt ID: (Human) Q9H0E2, (Rat) A2RUW1, (Mouse) Q9QZ06
Entrez Gene ID: (Human) 54472, (Rat) 361677, (Mouse) 54473
autophagy
inflammatory response
signal transduction
phosphorylation
epithelial cell differentiation
positive regulation of protein sumoylation
protein localization to endosome
innate immune response
immune system process
ubiquitin-dependent protein catabolic process
leukocyte activation
interleukin-1-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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