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Proteintech
CARD11 Monoclonal Antibody (3F5H6), CoraLite® Plus 488
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Product Details
CL488-68269
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3F5H6
Immunogen
CARD11 fusion protein Ag16468
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: DTMYQDRHEW LCARVDPFTD HDLDMGTIPS YSRAQQLLLV KLQRLMHRGS REEVDGTHHT LRALRNTLQP EEALSTSDPR VSPRLSRASF LFGQLLQFVS RSENKYKRMN SNERVRIISG SPLGSLARSS LDATKLLTEK QEELDPESEL GKNLSLIPYS LVRAFYCERR RPVLFTPTVL AKTLVQRLLN SGGAMEFTIC KSDIVTRDEF LRRQKTETII YSREKNPNAF ECIAPANIEA VAAKNKHCLL EAGIGCTRDL IKSNIYPIVL FIRVCEKNIK RFRKLLPRPE TEEEFLRVCR LKEKELEALP CLYATVEPDM WGSVEELLRV VKDKIGEEQR KTIWVDEDQL
Target Information
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bcl10-interacting maguk protein 3; CARD-containing MAGUK protein 1; Carma 1; caspase recruitment domain family, member 11; Caspase recruitment domain-containing protein 11; MGC133069
Gene Aliases: BENTA; BIMP3; CARD11; CARMA1; IMD11; PPBL
UniProt ID: (Human) Q9BXL7
Entrez Gene ID: (Human) 84433
positive regulation of cytokine production
stimulatory C-type lectin receptor signaling pathway
positive regulation of B cell proliferation
T cell costimulation
Fc-epsilon receptor signaling pathway
positive regulation of T cell proliferation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
thymic T cell selection
positive regulation of interleukin-2 biosynthetic process
regulation of B cell differentiation
regulation of T cell differentiation
GMP metabolic process
GDP metabolic process
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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