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Proteintech
SERCA3 Monoclonal Antibody (1A2C2), CoraLite® Plus 488
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Product Details
CL488-68287
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A2C2
Immunogen
SERCA3 fusion protein Ag4527
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: TRRMARKNAI VRSLPSVETL GCTSVICSDK TGTLTTNQMS VCRMFVVAEA DAGSCLLHEF TISGTTYTPE GEVRQGDQPV RCGQFDGLVE LATICALCND SALDYNEAKG VYEKVGEATE TALTCLVEKM NVFDTDLQAL SRVERAGACN TVIKQLMRKE FTLEFSRDRK SMSVYCTPTR PHPTGQGSKM FVKGAPESVI ERCSSVRVGS RTAPLTPTSR EQILAKIRDW GSGSDTLRCL ALATRDAPPR KEDMELDDCS KFVQYETDLT FVGCVGMLDP PRPEVAACIT RCYQAGIRVV MITGDNKGTA VAICRRLGIF GDTEDVAGKA YTGREFDDLS PEQQRQACRT ARCFARVEPA HKSRIVENLQ SFNEITAMTG DGVNDAPALK KAEIGIAMGS GTAVAKSAAE MVLSDDNFAS IVAAVEEGRA IYSNMKQFIR YLISSNVGEV VCIFLTAILG LPEALIPVQL LWVNLVTDGL PATALGFNPP DLDIMEKLPR SPREALISGW LFFRYLAIGV YVGLATVAAA TWWFVYDAEG PHINFYQLRN FLKCSEDNPL FAGIDCEVFE SRFPTTMALS VLVTIEMCNA LNSVSENQSL LRMPPWMNPW LLVAVAMSMA LHFLILLVPP LPLIFQVTPL SGRQWVVVLQ ISLPVILLDE ALKYLSRNHM HEEMSQK
Target Information
ATP dependent calcium pumps are responsible in part for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium ATPases (SERCA). The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific isoform expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. SERCA3 has been found to co-express with SERCA2b in platelets, mast cells, lymphoid cells, and epithelial cells. Due to this pattern of expression it is referred to as the non-muscle form of SERCA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenosine triphosphatase, calcium; ATPase, Ca(2+)-transporting, ubiquitous; ATPase, Ca++ transporting, ubiquitous; calcium ATPase; SERCA3f; Calcium pump 3; calcium-translocating P-type ATPase; sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump; sarco/endoplasmic reticulum Ca2+ -ATPase; sarcoendoplasmic reticulum Ca2+ ATPase type 3; Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; SERCA3; SERCA3D; SERCA3E; SR Ca(2+)-ATPase 3; unnamed protein product
Gene Aliases: ATP2A3; SERCA3; SERCA3b
UniProt ID: (Human) Q93084, (Rat) P18596, (Mouse) Q64518
Entrez Gene ID: (Human) 489, (Rat) 25391, (Mouse) 53313
nucleotide binding
calcium channel regulator activity
calcium-transporting ATPase activity
protein binding
ATP binding
cysteine-type endopeptidase activator activity involved in apoptotic process
calcium ion transmembrane transporter activity
ATPase activity
calcium-dependent ATPase activity
ion channel binding
metal ion binding
hydrolase activity
primary active transporter
ion transport
calcium ion transport
cellular calcium ion homeostasis
ion transmembrane transport
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
calcium ion transmembrane transport
transport across blood-brain barrier
calcium ion transport from cytosol to endoplasmic reticulum
regulation of cardiac conduction
metabolic process
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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