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Proteintech
PNPT1 Monoclonal Antibody (3F2A1), CoraLite® Plus 488
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Product Details
CL488-68309
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3F2A1
Immunogen
PNPT1 fusion protein Ag6290
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: YEFPPYATNE IGKVTGLNRR ELGHGALAEK ALYPVIPRDF PFTIRVTSEV LESNGSSSMA SACGGSLALM DSGVPISSAV AGVAIGLVTK TDPEKGEIED YRLLTDILGI EDYNGDMDFK IAGTNKGITA LQADIKLPGI PIKIVMEAIQ QASVAKKEIL QIMNKTISKP RASRKENGPV VETVQVPLSK RAKFVGPGGY NLKKLQAETG VTISQVDEET FSVFAPTPSA MHEARDFITE ICKDDQEQQL EFGAVYTATI TEIRDTGVMV KLYPNMTAVL LHNTQLDQRK IKHPTALGLE VGQEIQVKYF GRDPADGRMR LSRKVLQSPA TTVVRTLNDR SSIVMGEPIS QSSSNSQ
Target Information
PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondirla) is a RNA-binding protein implicated in numerous RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. PNPT1 is a component of the mitochondrial degradosome (mtEXO) complex that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. It is required for correct processing and polyadenylation of mitochondrial mRNAs. It plays a role as a cytoplasmic RNA import factor, in mitochondrial morphogenesis and respiration, regulation of expression of the electron transport chain, regulation of the stability of specific mature miRNAs in melanoma cells, and RNA cell surveilance. Mutations of the gene can result in combined oxidative phosphorylation deficiency 13 (COXPD13) and deafness, autosomal recessive, 70 (DFNB70).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3'-5' RNA exonuclease OLD35; DKFZp762K1914; old 35; Old-35; PNPase 1; PNPase old-35; Polynucleotide phosphorylase 1; Polynucleotide phosphorylase-like protein; Polyribonucleotide nucleotidyltransferase 1, mitochondrial
Gene Aliases: 1200003F12Rik; COXPD13; DFNB70; old-35; OLD35; PNPASE; PNPT1; Pnptl1; SCA25
UniProt ID: (Human) Q8TCS8, (Mouse) Q8K1R3
Entrez Gene ID: (Human) 87178, (Rat) 360992, (Mouse) 71701
3'-5'-exoribonuclease activity
nucleic acid binding
RNA binding
nuclease activity
exonuclease activity
polyribonucleotide nucleotidyltransferase activity
protein binding
poly(U) RNA binding
transferase activity
nucleotidyltransferase activity
hydrolase activity
poly(G) binding
miRNA binding
identical protein binding
poly(A) RNA binding
nucleotidyltransferase
mitochondrial RNA catabolic process
mitochondrial mRNA catabolic process
positive regulation of mitochondrial RNA catabolic process
mitochondrial RNA 5'-end processing
mitochondrial RNA 3'-end processing
RNA processing
mRNA processing
RNA catabolic process
mRNA catabolic process
mitochondrion organization
cellular response to oxidative stress
cellular response to interferon-beta
RNA import into mitochondrion
rRNA import into mitochondrion
regulation of cellular respiration
protein homooligomerization
response to cAMP
response to growth hormone
positive regulation of mRNA catabolic process
protein homotrimerization
nuclear polyadenylation-dependent mRNA catabolic process
mitochondrial mRNA polyadenylation
liver regeneration
positive regulation of miRNA catabolic process
regulation of cellular senescence
RNA polyadenylation
negative regulation of growth
mitochondrion morphogenesis
mitotic cell cycle arrest
RNA phosphodiester bond hydrolysis, exonucleolytic
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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