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Proteintech
DYNLT1 Monoclonal Antibody (2E3D4), CoraLite® Plus 488
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Product Details
CL488-68312
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2E3D4
Immunogen
DYNLT1 fusion protein Ag33072
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: MEDYQAAEET AFVVDEVSNI VKEAIESAIG GNAYQHSKVN QWTTNVVEQT LSQLTKLGKP FKYIVTCVIM QKNGAGLHTA SSCFWDSSTD GSCTVRWENK TMYCIVSAFG LSI
Target Information
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activator of G-protein signaling 2; AGS2; Dynein light chain Tctex-type 1; dynein light chain Tctex-type 1D; Protein CW-1; t-complex testis expressed 1; T-complex testis-specific protein 1; T-complex testis-specific protein 1 homolog; t-complex-associated-testis-expressed 1-like 1; TCTEL1; TCTEX-1; unnamed protein product
Gene Aliases: AGS2; CW-1; DYNLT1; TCTEL1; TCTEX-1; TCTEX1
UniProt ID: (Human) P63172, (Rat) Q9Z336, (Mouse) P51807
Entrez Gene ID: (Human) 6993, (Rat) 83462, (Mouse) 21648
establishment of mitotic spindle orientation
microtubule-based movement
nervous system development
regulation of G-protein coupled receptor protein signaling pathway
intracellular transport of viral protein in host cell
positive regulation of intracellular transport
viral entry into host cell
negative regulation of neurogenesis
cell division
microtubule-dependent intracellular transport of viral material towards nucleus
transport of viral material towards nucleus
intracellular protein transport
microtubule-based process
mitotic nuclear division
metabolic process
neuron projection morphogenesis
regulation of cytoskeleton organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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