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Proteintech

STUB1 Monoclonal Antibody (2E6B9), CoraLite® Plus 488

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Product Details

CL488-68407

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2E6B9

Immunogen

Peptide

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Target Information

A recently identified protein, termed carboxyl terminus of hsc70-interacting protein (CHIP), has been shown to interact both with the constitutive form of hsc70 and the stress inducible form, hsp70. This novel 35 kDa cytoplasmic protein has been shown to be highly expressed in striated muscle in vivo. Additional studies have shown that this protein is expressed over a broad range of cultured tissues. Through immunoprecipitation experiments, CHIP has been shown to directly bind to the carboxyl terminus of hsc70 and hsp70 where it decreases ATPase activity and reduces overall chaperone efficiency. CHIP has also been identified as an important protein in the ubiquitin-proteasome system. CHIP contains a U-box domain and acts as an E3 ubiquitin-ligase in conjunction with hsc70 and hsp90.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Antigen NY-CO-7; Carboxy terminus of Hsp70-interacting protein; CLL-associated antigen KW-8; E3 ubiquitin-protein ligase CHIP; heat shock protein A binding protein 2 (c-terminal); LA16c-313D11.6; RING-type E3 ubiquitin transferase CHIP; serologically defined colon cancer antigen 7; STIP1 homology and U box-containing protein 1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; tetratricopeptide repeat protein; TPR domain protein

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Gene Aliases: CHIP; HSPABP2; NY-CO-7; PP1131; SCA48; SCAR16; SDCCAG7; STUB1; UBOX1

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UniProt ID: (Human) Q9UNE7, (Rat) A6HD62

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Entrez Gene ID: (Human) 10273, (Rat) 287155

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Function(s)
G-protein coupled receptor binding ubiquitin-protein transferase activity protein binding transferase activity enzyme binding kinase binding Hsp70 protein binding protein binding, bridging TPR domain binding heat shock protein binding ubiquitin protein ligase binding ubiquitin-ubiquitin ligase activity protein homodimerization activity SMAD binding tau protein binding chaperone binding misfolded protein binding Hsp90 protein binding ubiquitin protein ligase activity R-SMAD binding ligase activity ubiquitin-protein ligase
Process(es)
MAPK cascade protein polyubiquitination response to ischemia DNA repair ubiquitin-dependent protein catabolic process protein monoubiquitination misfolded or incompletely synthesized protein catabolic process cellular response to DNA damage stimulus signal transduction positive regulation of metabolic process negative regulation of cardiac muscle hypertrophy protein ubiquitination negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response positive regulation of protein ubiquitination regulation of protein stability regulation of glucocorticoid metabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of smooth muscle cell apoptotic process positive regulation of smooth muscle cell apoptotic process cellular response to heat negative regulation of peroxisome proliferator activated receptor signaling pathway ERAD pathway ERBB2 signaling pathway negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of proteolysis protein stabilization protein autoubiquitination chaperone-mediated autophagy protein K63-linked ubiquitination cellular response to misfolded protein cellular response to hypoxia positive regulation of chaperone-mediated protein complex assembly positive regulation of mitophagy positive regulation of ERAD pathway negative regulation of vascular smooth muscle contraction ubiquitin-dependent SMAD protein catabolic process negative regulation of protein binding positive regulation of ubiquitin-protein transferase activity
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