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Phospho-S6 Ribosomal protein (Ser236) Recombinant Rabbit Monoclonal Antibody (7K17), CoraLite® Plus 488
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FIGURE: 1 / 1
Phospho-S6 Ribosomal protein (Ser236) Antibody (CL488-80206) in Flow
1X10^6 HEK-293 cells untreated (dashed lines) or treated with Calyculin A (red) were intracellularly stained with 0.25 µg CoraLite® Plus 488 Anti-Human Phospho-S6 Ribosomal protein (Ser236) (CL488-80206, Clone:7K17), or 0.25 µg Control Antibody (blue). Cells were fixed with 4% PFA and permeabilized with 90% MeOH.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL488-80206
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Mammalian cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7K17
Immunogen
Peptide
Conjugate
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 40S ribosomal protein S6; OTTHUMP00000021121; OTTHUMP00000021122; phosphoprotein NP33; ribosomal protein S6; RP11-513M16.6; RS6; unnamed protein product
Gene Aliases: eS6; S6; S6R
UniProt ID: (Human) P62753, (Mouse) P62754
Entrez Gene ID: (Human) 6194, (Mouse) 20104
ribosomal small subunit assembly
G1/S transition of mitotic cell cycle
mitotic cell cycle
placenta development
cytoplasmic translation
T cell proliferation involved in immune response
rRNA processing
translation
activation-induced cell death of T cells
gastrulation
positive regulation of cell proliferation
oogenesis stage
TOR signaling
response to insulin
T cell differentiation in thymus
ribosome biogenesis
ribosomal small subunit biogenesis
glucose homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
erythrocyte development
cellular response to ethanol
negative regulation of bicellular tight junction assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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