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Proteintech

Connexin 43 Recombinant Rabbit Monoclonal Antibody (3O6), CoraLite® Plus 488

View all (39) Connexin 43 antibodies

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Product Details

CL488-80543

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

3O6

Immunogen

Connexin 43 fusion protein Ag25533

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: FFKGVKDRV KGKSDPYHAT SGALSPAKDC GSQKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD NQNSKKLAAG HELQPLAIVD QRPSSRASSR ASSRPRPDDL EI

Target Information

Connexin 43 (Cx43), encoded by the GJA1 gene, is a widely expressed gap junction protein that plays an important role in direct cell-to-cell communication. Six Cx43 proteins assemble to form a connexon, or hemichannel, which can pair with a connexon on a neighboring cell to create a gap junction channel. These channels allow ions, metabolites, and small signaling molecules to pass between adjacent cells, helping coordinate processes such as electrical conduction, tissue development, wound healing, and cellular homeostasis. Cx43 is especially abundant in tissues such as the heart, brain, bone, and skin, and changes in its expression, localization, or function have been associated with cardiovascular disease, neurological disorders, impaired tissue repair, and cancer. Because of its broad role in intercellular signaling and disease biology, Cx43 is an important target for studying gap junction function and developing potential therapeutic strategies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha 1 connexin; connexin 43; connexin k1; connexin-43; Cx-43; CXA1; DFNB38; gap junction 43 kDa heart protein; gap junction membrane channel protein; gap junction membrane channel protein alpha 1; gap junction protein, alpha 1, 43kDa; GJA1; Npm1; ODD; ODOD; SDTY3; Syndactyly type III; unnamed protein product; VEGF

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Gene Aliases: AVSD3; CMDR; Cnx43; connexin43; CX43; Cx43alpha1; Cxnk1; EKVP; EKVP3; Gja-1; GJAL; HLHS1; HSS; Npm1; ODDD; PPKCA

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UniProt ID: (Human) P17302, (Mouse) P23242, (Rat) P08050

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Entrez Gene ID: (Pig) 100518636, (Human) 2697, (Mouse) 14609, (Rat) 24392

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Function(s)
tubulin binding gap junction hemi-channel activity receptor binding gap junction channel activity protein binding beta-catenin binding ion transmembrane transporter activity efflux transmembrane transporter activity transmembrane transporter activity glutathione transmembrane transporter activity alpha-tubulin binding beta-tubulin binding gap junction channel activity involved in cardiac conduction electrical coupling scaffold protein binding gap junction channel activity involved in cell communication by electrical coupling protein tyrosine kinase binding channel activity SH3 domain binding protein domain specific binding PDZ domain binding connexin binding disordered domain specific binding gap junction
Process(es)
response to ischemia spermatogenesis heart development response to wounding negative regulation of cell growth cellular response to platelet-derived growth factor stimulus regulation of apoptotic process bone remodeling transmembrane transport bone development positive regulation of smooth muscle cell chemotaxis microtubule-based transport establishment of mitotic spindle orientation cardiac conduction system development cell communication signal transduction cell-cell signaling protein localization male gonad development positive regulation of gene expression cell communication by electrical coupling glutamate secretion gap junction assembly negative regulation of gonadotropin secretion ion transmembrane transport glutathione transmembrane transport maintenance of blood-brain barrier T cell proliferation T cell activation xenobiotic transport positive regulation of I-kappaB kinase/NF-kappaB signaling cell-cell junction organization cellular response to pH atrial cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction positive regulation of cold-induced thermogenesis export across plasma membrane negative regulation of trophoblast cell migration regulation of blood circulation cellular response to beta-amyloid positive regulation of vascular smooth muscle cell proliferation positive regulation of morphogenesis of an epithelium positive regulation of mesodermal cell differentiation positive regulation of stem cell proliferation osteoblast differentiation in utero embryonic development neuron migration negative regulation of endothelial cell proliferation heart looping epithelial cell maturation lens development in camera-type eye chronic inflammatory response positive regulation of glomerular filtration atrial ventricular junction remodeling epicardial cell to mesenchymal cell transition positive regulation of cytosolic calcium ion concentration adult heart development regulation of heart contraction negative regulation of cell proliferation response to pH vascular transport negative regulation of gene expression cell communication by chemical coupling regulation of cell communication by electrical coupling positive regulation of cell communication by chemical coupling ATP transport regulation of bone mineralization positive regulation of insulin secretion embryonic heart tube development maintenance of protein localization in endoplasmic reticulum vasodilation embryonic digit morphogenesis skeletal muscle tissue regeneration positive regulation of protein catabolic process positive regulation of meiotic nuclear division positive regulation of striated muscle tissue development positive regulation of vasoconstriction regulation of bone remodeling blood vessel morphogenesis neuron projection morphogenesis regulation of body fluid levels regulation of calcium ion transport negative regulation of cardiac muscle cell proliferation milk ejection regulation of ventricular cardiac muscle cell membrane repolarization regulation of blood vessel remodeling regulation of atrial cardiac muscle cell membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization cardiac conduction establishment of epithelial cell polarity regulation of actin filament organization positive regulation of establishment of Sertoli cell barrier negative regulation of DNA biosynthetic process regulation of bicellular tight junction assembly positive regulation of behavioral fear response endothelium development response to glucose response to estradiol response to lipopolysaccharide response to retinoic acid response to fluid shear stress response to peptide hormone decidualization cellular response to mechanical stimulus cellular response to parathyroid hormone stimulus epididymis development
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