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Proteintech
SNAI1 Recombinant Rabbit Monoclonal Antibody (240164C2), CoraLite® Plus 488
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Product Details
CL488-81584-4
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240164C2
Immunogen
SNAI1 fusion protein Ag24248
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LQDSNPEFTF QQPYDQAHLL AAIPPPEILN PTASLPMLIW DSVLAPQAQP IAWASLRLQE SPRVAELTSL SDEDSGKGSQ PPSPPSPAPS SFSSTSVSSL EAEAYAAFPG LGQVPKQLAQ LSEAKDLQAR KAFNCKYCNK EYL
Target Information
Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stromamay be anew putative prognosis marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein sna; Protein snail homolog 1; similar to Mus musculus zinc finger protein Sna and to Drosophila melanogaster snail protein; Sna protein; snai; snail 1; snail 1 homolog; snail 1 zinc finger protein; snail family zinc finger 1; snail homolog 1; unnamed protein product; Zinc finger protein SNAI1; zinc-finger protein
Gene Aliases: AI194338; dJ710H13.1; SLUGH2; SNA; Sna1; SNAH; SNAI1; SNAIL; SNAIL1
UniProt ID: (Human) O95863, (Mouse) Q02085
Entrez Gene ID: (Human) 6615, (Mouse) 20613, (Rat) 116490
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
zinc ion binding
kinase binding
sequence-specific DNA binding
metal ion binding
E-box binding
sequence-specific double-stranded DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
nucleic acid binding
transcription factor activity, sequence-specific DNA binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
mesoderm formation
epithelial to mesenchymal transition
aortic valve morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
mesoderm development
epithelial cell migration
positive regulation of epithelial to mesenchymal transition
negative regulation of vitamin D biosynthetic process
positive regulation of cell migration
hair follicle morphogenesis
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
mesenchymal cell differentiation
palate development
canonical Wnt signaling pathway
cartilage morphogenesis
trophoblast giant cell differentiation
negative regulation of cell differentiation involved in embryonic placenta development
left/right pattern formation
heterochromatin organization
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
regulation of bicellular tight junction assembly
transcription from RNA polymerase II promoter
multicellular organism development
cell migration
Notch signaling involved in heart development
negative regulation of cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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