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DDX3 Recombinant Rabbit Monoclonal Antibody (5C12), CoraLite® Plus 488

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Product Details

CL488-81903

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

5C12

Immunogen

DDX3 fusion protein Ag1614

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: DLERGCHLL VATPGRLVDM MERGKIGLDF CKYLVLDEAD RMLDMGFEPQ IRRIVEQDTM PPKGVRHTMM FSATFPKEIQ MLARDFLDEY IFLAVGRVGS TSENITQKVV WVEESDKRSF LLDLLNATGK DSLTLVFVET KKGADSLEDF LYHEGYACTS IHGDRSQRDR EEALHQFRSG KSPILVATAV AARGLDISNV KHVINFDLPS DIEEYVHRIG RTGRVGNLGL ATSFFNERNI NITKDLLDLL VEAKQEVPSW LENMAYEHHY KGSSRGRSKS SRFSGGFGAR DYRQSSGASS SSFSSSRASS SRSGGGGHGS SRGFGGGGYG GFYNSDGYGG NYNSQGVDWW GN

Target Information

The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-dependent RNA helicase DDX3X; CAP-Rf; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3; D1Pas1-related sequence 2; DBX; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3; DEAD box protein 3, X-chromosomal; DEAD box RNA helicase DEAD3; DEAD box, X isoform; DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2); DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked; DEAD/H box-3; Embryonic RNA helicase; fibroblast growth factor inducible 14; Helicase-like protein 2; HLP2; mDEAD3; unnamed protein product

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Gene Aliases: CAP-Rf; D1Pas1-rs2; DBX; DDX14; DDX3; DDX3X; Dead3; Erh; Fin14; HLP2; MRX102; MRXSSB

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UniProt ID: (Human) O00571, (Mouse) Q62167

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Entrez Gene ID: (Human) 1654, (Rat) 317335, (Mouse) 13205

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Function(s)
nucleotide binding nucleic acid binding DNA binding DNA helicase activity RNA binding RNA helicase activity mRNA binding GTPase activity helicase activity protein binding ATP binding transcription factor binding poly(A) binding eukaryotic initiation factor 4E binding hydrolase activity ATPase activity nucleoside-triphosphatase activity translation initiation factor binding RNA strand annealing activity signaling adaptor activity RNA stem-loop binding gamma-tubulin binding ribosomal small subunit binding CTPase activity protein serine/threonine kinase activator activity cadherin binding mRNA 5'-UTR binding ATP-dependent DNA helicase activity ATP-dependent RNA helicase activity poly(A) RNA binding
Process(es)
immune system process cytoplasmic pattern recognition receptor signaling pathway translational initiation regulation of translation apoptotic process chromosome segregation gamete generation extrinsic apoptotic signaling pathway via death domain receptors response to virus positive regulation of gene expression negative regulation of gene expression Wnt signaling pathway negative regulation of translation cell differentiation positive regulation of cell growth negative regulation of cell growth negative regulation of protein complex assembly positive regulation of type I interferon production positive regulation of interferon-alpha production positive regulation of interferon-beta production stress granule assembly positive regulation of toll-like receptor 7 signaling pathway positive regulation of toll-like receptor 8 signaling pathway intracellular signal transduction positive regulation of translation in response to endoplasmic reticulum stress ribosome biogenesis mature ribosome assembly positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of viral genome replication innate immune response positive regulation of translation positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation lipid homeostasis positive regulation of mitochondrial translation cellular response to arsenic-containing substance cellular response to osmotic stress positive regulation of chemokine (C-C motif) ligand 5 production positive regulation of canonical Wnt signaling pathway intrinsic apoptotic signaling pathway cellular response to virus positive regulation of G1/S transition of mitotic cell cycle positive regulation of NLRP3 inflammasome complex assembly negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein K63-linked ubiquitination protein localization to cytoplasmic stress granule negative regulation of intrinsic apoptotic signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated regulation of gene expression RNA secondary structure unwinding DNA duplex unwinding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
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