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P21 Recombinant Rabbit Monoclonal Antibody (3N14), CoraLite® Plus 488

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P21 Recombinant Rabbit Monoclonal Antibody (3N14), CoraLite® Plus 488

Product Details

CL488-82669-2

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

3N14

Immunogen

P21 fusion protein Ag0368
3D Epitope / Immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV PRSGEQAEGS PGGPGDSQGR KRRQTSMTD

Target Information

Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activating Fragment 1; alternate gene name=WAF1; CDK-interacting protein 1; CDK-interaction protein 1; CDKN1A; CDNK1A; Cip1); cyclin kinase inhibitor; Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1A (p21; cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; DNA synthesis inhibitor; MDA-6; melanoma differentiation associated protein 6; Melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; OTTHUMP00000016298; p21; p21; p21Cip1/Waf1; putative DNA synthesis inhibitor; SLC12A9; unnamed protein product; Wild type p53 activated fragment 1 (WAF1); wild type p53 activated fragment-1; wild-type p53-activated fragment 1

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Gene Aliases: CAP20; CDKI; CDKN1; CDKN1A; CIP1; MDA-6; MDA6; P21; p21CIP1; p21WAF; PIC1; SDI1; WAF1

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UniProt ID: (Human) P38936, (Mouse) P39689

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Entrez Gene ID: (Human) 1026, (Mouse) 12575

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Function(s)
protein kinase inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding zinc ion binding protein kinase binding cyclin binding ubiquitin protein ligase binding macromolecular complex binding metal ion binding protein serine/threonine kinase binding protein sequestering activity molecular function activator activity molecular function inhibitor activity cyclin-dependent protein kinase activating kinase activity protein complex binding kinase inhibitor
Process(es)
G1/S transition of mitotic cell cycle in utero embryonic development protein import into nucleus cellular response to DNA damage stimulus mitotic G2 DNA damage checkpoint Ras protein signal transduction regulation of mitotic cell cycle heart development positive regulation of cell proliferation negative regulation of cell proliferation epidermis development response to UV regulation of G2/M transition of mitotic cell cycle negative regulation of macromolecule biosynthetic process negative regulation of gene expression keratinocyte differentiation negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator positive regulation of B cell proliferation mitotic G1 DNA damage checkpoint cellular response to amino acid starvation wound healing tissue regeneration signal transduction in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of programmed cell death keratinocyte proliferation positive regulation of DNA replication positive regulation of protein kinase activity negative regulation of growth fibroblast proliferation positive regulation of fibroblast proliferation nuclear import regulation of cell cycle cellular response to cell-matrix adhesion cellular response to ionizing radiation cellular response to gamma radiation cellular response to UV-B signal transduction by p53 class mediator cellular senescence replicative senescence stress-induced premature senescence oncogene-induced cell senescence intrinsic apoptotic signaling pathway regulation of cell cycle G1/S phase transition negative regulation of cyclin-dependent protein kinase activity negative regulation of vascular smooth muscle cell proliferation negative regulation of cardiac muscle tissue regeneration regulation of G1/S transition of mitotic cell cycle negative regulation of G1/S transition of mitotic cell cycle regulation of DNA biosynthetic process negative regulation of DNA biosynthetic process positive regulation of reactive oxygen species metabolic process regulation of cyclin-dependent protein serine/threonine kinase activity G2/M transition of mitotic cell cycle protein phosphorylation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest cell cycle cell cycle arrest cellular response to extracellular stimulus regulation of protein import into nucleus, translocation negative regulation of phosphorylation negative regulation of apoptotic process negative regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle arrest
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