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Proteintech
Emerin Recombinant Rabbit Monoclonal Antibody (230089C4), CoraLite® Plus 488
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Product Details
CL488-82888-2
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
230089C4
Immunogen
Emerin fusion protein Ag0236
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: STRGDADMYD LPKKEDALLY QSKGYNDDYY EESYFTTRTY GEPESAGPSR AVRQSVTSFP DADAFHHQVH DDDLLSSSEE ECKDRERPMY GRDSAYQSIT HYRPVSASRS SLDLSYYPTS SSTSFMSSSS SSSSWLTRRA IRPENRAPGA GLGQDRQVPL WGQLLLFLVF VIVLFFIYHF MQAEEGN
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EMD; Emerin; LEM domain containing 5
Gene Aliases: EDMD; EMD; LEMD5; STA
UniProt ID: (Human) P50402
Entrez Gene ID: (Human) 2010
muscle contraction
muscle organ development
skeletal muscle cell differentiation
positive regulation of protein export from nucleus
negative regulation of fibroblast proliferation
regulation of canonical Wnt signaling pathway
cellular response to growth factor stimulus
nuclear membrane organization
negative regulation of canonical Wnt signaling pathway
amyloid fibril formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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