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Proteintech
PCSK9 Recombinant Rabbit Monoclonal Antibody (230536E4), CoraLite® Plus 488
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Product Details
CL488-83004-4
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
230536E4
Immunogen
PCSK9 fusion protein Eg0640
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: QDEDGDYEEL MLALPSQEDG LADEAAHVAT ATFRRCSKEA WRLPGTYIVV LMEETQRLQI EQTAHRLQTR AARRGYVIKV LHIFYDLFPG FLVKMSSDLL GLALKLPHVE YIEEDSFVFA QSIPWNLERI IPAWHQTEED RSPDGSSQVE VYLLDTSIQG AHREIEGRVT ITDFNSVPEE DGTRFHRQAS KCDSHGTHLA GVVSGRDAGV AKGTSLHSLR VLNCQGKGTV SGTLIGLEFI RKSQLIQPSG PLVVLLPLAG GYSRILNAAC RHLARTGVVL VAAAGNFRDD ACLYSPASAP EVITVGATNA QDQPVTLGTL GTNFGRCVDL FAPGKDIIGA SSDCSTCFMS QSGTSQAAAH VAGIVARMLS REPTLTLAEL RQRLIHFSTK DVINMAWFPE DQQVLTPNLV ATLPPSTHET GGQLLCRTVW SAHSGPTRTA TATARCAPEE ELLSCSSFSR SGRRRGDWIE AIGGQQVCKA LNAFGGEGVY AVARCCLVPR ANCSIHNTPA ARAGLETHVH CHQKDHVLTG CSFHWEVEDL SVRRQPALRS RRQPGQCVGH QAASVYASCC HAPGLECKIK EHGISGPSEQ VTVACEAGWT LTGCNVLPGA SLTLGAYSVD NLCVARVHDT ARADRTSGEA TVAAAICCRS RPSAKASWVQ
Target Information
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: convertase subtilisin; hypercholesterolemia; NARC-1; neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; OTTHUMP00000009833; PC9; Proprotein convertase 9; proprotein convertase PC9; Proprotein convertase subtilisin/kexin type 9; Subtilisin/kexin-like protease PC9
Gene Aliases: AI415265; AI747682; FH3; HCHOLA3; Narc1; PC9; Pcsk9
UniProt ID: (Mouse) Q80W65
Entrez Gene ID: (Mouse) 100102
serine-type endopeptidase activity
peptidase activity
serine-type peptidase activity
hydrolase activity
sodium channel inhibitor activity
low-density lipoprotein particle binding
receptor inhibitor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
protein self-association
poly(A) RNA binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding
serine protease
negative regulation of receptor recycling
positive regulation of receptor internalization
proteolysis
lipid metabolic process
triglyceride metabolic process
phospholipid metabolic process
apoptotic process
lysosomal transport
steroid metabolic process
cholesterol metabolic process
cellular response to starvation
regulation of receptor activity
negative regulation of low-density lipoprotein particle clearance
protein processing
protein autoprocessing
neuron differentiation
low-density lipoprotein receptor particle metabolic process
low-density lipoprotein particle receptor catabolic process
regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
lipoprotein metabolic process
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of receptor activity
negative regulation of sodium ion transmembrane transporter activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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