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Proteintech
Osteopontin Recombinant Rabbit Monoclonal Antibody (240250A1), CoraLite® Plus 488
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Product Details
CL488-83413-6
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240250A1
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: LPVKVTDSGS SEEKLYSLHP DPIATWLVPD PSQKQNLLAP QNAVSSEEKD DFKQETLPSN SNESHDHMDD DDDDDDDDGD HAESEDSVDS DESDESHHSD ESDETVTAST QADTFTPIVP TVDVPNGRGD SLAYGLRSKS RSFQVSDEQY PDATDEDLTS HMKSGESKES LDVIPVAQLL SMPSDQDNNG KGSHESSQLD EPSLETHRLE HSKESQESAD QSDVIDSQAS SKASLEHQSH KFHSHKDKLV LDPKSKEDDR YLKFRISHEL ESSSSEVN
Target Information
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2AR; 44 kDa bone phosphoprotein; Bone sialoprotein 1; Bone sialoprotein 1 (BSPI/BSP1); Calcium oxalate crystal growth inhibitor protein; CALPHA1 fusion; Early T lymphocyte activation 1 (ETA1); Early T-lymphocyte activation 1 protein; HGNC:11255; immunoglobulin alpha 1 heavy chain constant region fusion protein; MGC110940; Minopontin; Osteopontin; osteopontin-like protein; Secreted phosphoprotein 1; secreted phosphoprotein 1 (osteopontin bone sialoprotein I early T lymphocyte activation 1); Secreted phosphoprotein 1 (SPP1); SPP-1; urinar
Gene Aliases: 2AR; Apl-1; BNSP; Bsp; BSPI; Eta; ETA-1; OP; Opn; Opnl; Ric; Spp-1; Spp1
UniProt ID: (Mouse) P10923
Entrez Gene ID: (Mouse) 20750
ossification
osteoblast differentiation
cell adhesion
response to organic substance
positive regulation of cell-substrate adhesion
neutrophil chemotaxis
biomineral tissue development
response to vitamin D
negative regulation of apoptotic process
positive regulation of bone resorption
response to steroid hormone
cellular response to fluid shear stress
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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