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Proteintech
CHI3L1/YKL40 Recombinant Rabbit Monoclonal Antibody (240691F11), CoraLite® Plus 488
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Product Details
CL488-83685-4
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240691F11
Immunogen
CHI3L1/YKL40 fusion protein Ag33123
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: FRGQEDASPD RFSNTDYAVG YMLRLGAPAS KLVMGIPTFG RSFTLASSET GVGAPISGPG IPGRFTKEAG TLAYYEICDF LRGATVHRIL GQQVPYATKG NQWVGYDDQE SVKSKVQYLK DRQLAGAMVW ALDLDDFQGS FCGQDLRFPL TNAIKDALAA T
Target Information
Human cartilage glycoprotein 39 (GP-39), also known as YKL-40, is a glycoprotein secreted by articular chondrocytes, synoviocytes and macrophages. Serum and synovial fluid GP-39 levels are elevated in inflammatory diseases and correlate with the degree of joint destruction in rheumatoid arthritis. GP-39 is expressed in articular chondrocytes and synovial cells, as well as in liver, but is undetectable in muscle tissues, lung, pancreas, mononuclear cells and fibroblasts. GP-39 is a candidate autoantigen in rheumatoid arthritis and is important in the capacity of cells to respond to and cope with changes in their environment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 39 kDa synovial protein; Cartilage glycoprotein 39; CGP-39; CGP39; Chitinase 3 like protein 1CGP 39; chitinase 3-like 1 (cartilage glycoprotein-39); Chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; hCGP39; unnamed protein product; YKL-40
Gene Aliases: ASRT7; CGP-39; CHI3L1; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40
UniProt ID: (Human) P36222
Entrez Gene ID: (Human) 1116
carbohydrate metabolic process
chitin catabolic process
apoptotic process
inflammatory response
activation of NF-kappaB-inducing kinase activity
response to mechanical stimulus
positive regulation of peptidyl-threonine phosphorylation
lung development
positive regulation of interleukin-8 production
response to tumor necrosis factor
positive regulation of angiogenesis
cartilage development
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
response to interleukin-6
cellular response to tumor necrosis factor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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