Search
Proteintech
NCAM1/CD56 Recombinant Rabbit Monoclonal Antibody (240936B10), CoraLite® Plus 488
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
CL488-83883-5
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240936B10
Immunogen
Fusion Protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: LQVDIVPSQG EISVGESKFF LCQVAGDAKD KDISWFSPNG EKLSPNQQRI SVVWNDDDSS TLTIYNANID DAGIYKCVVT AEDGTQSEAT VNVKIFQKLM FKNAPTPQEF KEGEDAVIVC DVVSSLPPTI IWKHKGRDVI LKKDVRFIVL SNNYLQIRGI KKTDEGTYRC EGRILARGEI NFKDIQVIVN VPPTVQARQS IVNATANLGQ SVTLVCDADG FPEPTMSWTK DGEPIENEEE DDEKHIFSDD SSELTIRNVD KNDEAEYVCI AENKAGEQDA SIHLKVFAKP KITYVENQTA MELEEQVTLT CEASGDPIPS ITWRTSTRNI SSEEKTLDGH MVVRSHARVS SLTLKSIQYT DAGEYICTAS NTIGQDSQSM YLEFQYAPKL QGPVAVYTWE GNQVNITCEV FAYPSATISW FRDGQLLPSS NYSNIKIYNT PSASYLEVTP DSENDFGNYN CTAVNRIGQE SLEFILVQAD TPSSPSIDRV EPYSSTAQVQ FDEPEATGGV PILKYKAEWK SLGEESWHFK WYDAKEANME GIVTIMGLKP ETRYSVRLAA LNGKGLGEIS AATEFKTQPV REPSAPKLEG QMGEDGNSIK VNLIKQDDGG SPIRHYLVKY RALASEWKPE IRLPSGSDHV MLKSLDWNAE YEVYVVAENQ QGKSKAAHFV FRTSAQPTAI PANGSPTAGL ST
Target Information
CD56, also known as neural cell adhesion molecule (NCAM), is a highly glycosylated transmembrane glycoprotein of the immunoglobulin family. It plays a crucial role in cell adhesion, migration, axonal growth, pathfinding, and synaptic plasticity. CD56 is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa and is involved in homotypic adhesion of neural cells. It mediates interactions by binding extracellular matrix components such as laminin and integrins, with polysialic modification reducing CD56-mediated adhesion. In the hematopoietic system, CD56 is expressed on natural killer (NK) cells and a subset of T cells known as NKT cells. It is also found on most neuroectodermal-derived cell lines, tissues, and neoplasms, including retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. CD56 serves as a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms, highlighting its importance in both neural and immune system functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CD-56; CD56; E NCAM; N CAM1; N-CAM-1; neural cell adhesion molecule; Neural cell adhesion molecule 1; sCD56; sNCAM; soluble CD56; soluble NCAM
Gene Aliases: CD56; E-NCAM; Ncam; NCAM-1; Ncam1
UniProt ID: (Mouse) P13595
Entrez Gene ID: (Mouse) 17967
regulation of exocyst assembly
cell adhesion
cell surface receptor signaling pathway
aging
learning or memory
response to lead ion
response to fluoxetine
thalamus development
neuron projection development
multicellular organismal response to stress
homotypic cell-cell adhesion
response to cocaine
neuron development
positive regulation of calcium-mediated signaling
regulation of sensory perception of pain
positive regulation of cardiac muscle cell proliferation
negative regulation of cell death
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support