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Proteintech
MCP-1 Recombinant Rabbit Monoclonal Antibody (230483A9), CoraLite® Plus 488
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FIGURE: 1 / 2
MCP-1 Antibody (CL488-98028) in Flow
1x10^6 LPS and Brefeldin A treated RAW 264.7 cells were intracellularly stained with 0.25 µg CoraLite® Plus 488 Anti-Mouse MCP-1 Rabbit Recombinant Antibody (CL488-98028, Clone: 230483A9) (red) or Isotype Control (blue). 1x10^6 untreated RAW 264.7 cells were intracellularly stained with 0.25 µg CoraLite® Plus 488 Anti-Mouse MCP-1 Rabbit Recombinant Antibody (CL488-98028, Clone: 230483A9) (black, dashed). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-98028
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
230483A9
Immunogen
Fusion Protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Target Information
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C motif chemokine 2; H-MCP-1; MCP-1; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; Monocyte chemotactic protein 1; Platelet-derived growth factor-inducible protein JE; RP23-350G1.3; small inducible cytokine A2; Small-inducible cytokine A2
Gene Aliases: AI323594; Ccl2; HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje; SMC-CF
UniProt ID: (Mouse) P10148
Entrez Gene ID: (Mouse) 20296
angiogenesis
positive regulation of leukocyte mediated cytotoxicity
positive regulation of endothelial cell proliferation
leukocyte migration involved in inflammatory response
positive regulation of leukocyte migration
positive regulation of cellular extravasation
cellular calcium ion homeostasis
chemotaxis
inflammatory response
immune response
cytoskeleton organization
transforming growth factor beta receptor signaling pathway
glial cell migration
regulation of cell shape
response to heat
response to wounding
regulation of vascular endothelial growth factor production
positive regulation of macrophage chemotaxis
negative regulation of angiogenesis
cytokine-mediated signaling pathway
positive regulation of cell-cell adhesion
neutrophil chemotaxis
positive regulation of tumor necrosis factor production
positive regulation of collagen biosynthetic process
helper T cell extravasation
monocyte homeostasis
positive regulation of cell adhesion
vascular endothelial growth factor receptor signaling pathway
eosinophil chemotaxis
macrophage chemotaxis
lymphocyte chemotaxis
positive regulation of synaptic transmission
positive regulation of T cell activation
positive regulation of nitric-oxide synthase biosynthetic process
chemokine-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
positive regulation of monocyte chemotaxis
positive regulation of immune complex clearance by monocytes and macrophages
positive regulation of protein targeting to membrane
positive regulation of apoptotic cell clearance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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