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Proteintech
CSK Monoclonal Antibody (3B12C5), CoraLite® Plus 488
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Product Details
CL48866115100UL
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3B12C5
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-Src kinase; c-src tyrosine kinase; CSK; CSK, non-receptor tyrosine kinase; MGC117393; p50CSK; Protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK; unnamed protein product
Gene Aliases: AW212630; CSK; p50CSK
UniProt ID: (Human) P41240, (Mouse) P41241
Entrez Gene ID: (Human) 1445, (Mouse) 12988
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein phosphatase binding
protein kinase A catalytic subunit binding
identical protein binding
metal ion binding
proline-rich region binding
protein tyrosine kinase binding
adaptive immune response
immune system process
regulation of immune system process
protein phosphorylation
negative regulation of cell proliferation
negative regulation of low-density lipoprotein particle clearance
T cell costimulation
negative regulation of interleukin-6 production
adherens junction organization
intracellular signal transduction
negative regulation of Golgi to plasma membrane protein transport
negative regulation of bone resorption
oligodendrocyte differentiation
negative regulation of phagocytosis
T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
regulation of multicellular organismal process
regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of ERK1 and ERK2 cascade
cellular response to peptide hormone stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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