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Proteintech
Kininogen 1 Monoclonal Antibody (10E8D11), CoraLite® Plus 488
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Product Details
CL48866123100UL
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
10E8D11
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-2-thiol proteinase inhibitor; bradykinin; Fitzgerald factor; High molecular weight kininogen; HMWK; Kininogen-1; prepro alpha-2-thiol proteinase inhibitor; unnamed protein product; Williams-Fitzgerald-Flaujeac factor
Gene Aliases: BDK; BK; HAE6; HK; HMWK; KNG; KNG1
UniProt ID: (Human) P01042
Entrez Gene ID: (Human) 3827
inflammatory response
negative regulation of cell adhesion
signal transduction
positive regulation of cytosolic calcium ion concentration
blood coagulation
hemostasis
negative regulation of blood coagulation
killing of cells of other organism
vasodilation
positive regulation of apoptotic process
negative regulation of proteolysis
negative regulation of multicellular organismal process
antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of blood vessel diameter
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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