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Proteintech
TWIST2 Monoclonal Antibody (1B12D11), CoraLite® Plus 488
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Product Details
CL48866544100UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B12D11
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHa39; Class A basic helix-loop-helix protein 39; dermis expressed 1; Dermis-expressed protein 1; Dermo-1; dermo-1 protein; twist basic helix-loop-helix transcription factor 2; twist homolog 2; twist-related bHLH protein Dermo1; Twist-related protein 2
Gene Aliases: AMS; BBRSAY; BHLHA39; DERMO1; FFDD3; SETLSS; TWIST2
UniProt ID: (Human) Q8WVJ9, (Mouse) Q9D030, (Rat) P97831
Entrez Gene ID: (Human) 117581, (Mouse) 13345, (Rat) 59327
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
protein binding
protein dimerization activity
transcription factor activity, RNA polymerase II transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein domain specific binding
molecular_function
basic helix-loop-helix transcription factor
regulation of transcription from RNA polymerase II promoter
cell differentiation
positive regulation of cell migration
developmental process
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
negative regulation of cell proliferation
positive regulation of keratinocyte proliferation
negative regulation of tumor necrosis factor production
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation of molecular function
negative regulation of myeloid cell differentiation
embryonic cranial skeleton morphogenesis
face morphogenesis
cornea development in camera-type eye
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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