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Proteintech
Alpha 2-Antiplasmin Monoclonal Antibody (3F6C3), CoraLite® Plus 488
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Product Details
CL48867308100UL
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3F6C3
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-2-antiplasmin; alpha-2-antiplasmin precursor; Alpha-2-AP; Alpha-2-PI; Alpha-2-plasmin inhibitor; plasmin inhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Serpin F2; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; unnamed protein product
Gene Aliases: A2AP; AAP; ALPHA-2-PI; alpha2AP; API; PLI; SERPINF2
UniProt ID: (Human) P08697
Entrez Gene ID: (Human) 5345
regulation of blood vessel size by renin-angiotensin
acute-phase response
negative regulation of plasminogen activation
collagen fibril organization
positive regulation of collagen biosynthetic process
fibrinolysis
positive regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
blood vessel morphogenesis
positive regulation of smooth muscle cell proliferation
positive regulation of coagulation
positive regulation of stress fiber assembly
negative regulation of fibrinolysis
positive regulation of ERK1 and ERK2 cascade
positive regulation of transforming growth factor beta production
positive regulation of cell-cell adhesion mediated by cadherin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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