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ACVR1 Monoclonal Antibody (1F11B10), CoraLite® Plus 488

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ACVR1 Monoclonal Antibody (1F11B10), CoraLite® Plus 488

Product Details

CL48867417100UL

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1F11B10

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Wet ice

Target Information

Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; ACTR-I; ALK-2; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; TSR-I; unnamed protein product

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Gene Aliases: ActR-I; ACTRI; ActRIA; Acvr; ACVR1; ACVR1A; ACVRLK2; Alk-2; ALK2; Alk8; D330013D15Rik; FOP; SKR1; Tgfb1; Tsk7L; TSRI

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UniProt ID: (Human) Q04771, (Mouse) P37172

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Entrez Gene ID: (Human) 90, (Mouse) 11477

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta receptor activity, type I protein binding ATP binding kinase activity activin receptor activity, type I transferase activity peptide hormone binding growth factor binding protein homodimerization activity cadherin binding SMAD binding metal ion binding activin binding transforming growth factor beta binding BMP receptor activity protein tyrosine kinase binding receptor signaling protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
patterning of blood vessels osteoblast differentiation in utero embryonic development gastrulation with mouth forming second mesoderm formation neural crest cell migration acute inflammatory response embryonic heart tube morphogenesis outflow tract septum morphogenesis atrioventricular valve morphogenesis mitral valve morphogenesis endocardial cushion formation endocardial cushion fusion atrial septum primum morphogenesis transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway germ cell development determination of left/right symmetry gastrulation mesoderm development heart development dorsal/ventral pattern formation negative regulation of signal transduction cell differentiation regulation of ossification positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway activin receptor signaling pathway negative regulation of activin receptor signaling pathway endothelial cell differentiation positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation positive regulation of multicellular organismal process pharyngeal system development positive regulation of SMAD protein import into nucleus ventricular septum morphogenesis epithelial tube morphogenesis cardiac muscle cell fate commitment endocardial cushion cell fate commitment positive regulation of cardiac epithelial to mesenchymal transition cellular response to growth factor stimulus cellular response to BMP stimulus circulatory system development positive regulation of intracellular signal transduction positive regulation of determination of dorsal identity regulation of multicellular organismal development negative regulation of G1/S transition of mitotic cell cycle negative regulation of extrinsic apoptotic signaling pathway G1/S transition of mitotic cell cycle urogenital system development protein phosphorylation embryo development positive regulation of pathway-restricted SMAD protein phosphorylation phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation intracellular signal transduction pathway-restricted SMAD protein phosphorylation
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