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Ins1 Monoclonal Antibody (1H2C11), CoraLite® Plus 488

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Ins1 Monoclonal Antibody (1H2C11), CoraLite® Plus 488

Product Details

CL48867668100UL

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:300
-

Immunocytochemistry (ICC/IF)

1:150-1:600
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1H2C11

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

0.94 mg/mL

Amount

94 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Wet ice

Target Information

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ins; Insulin-1; Insulin-2

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Gene Aliases: AA986540; Ins-1; Ins-2; Ins1; Ins2; Ins2-rs1; InsII; Mody; Mody4; proinsulin

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UniProt ID: (Rat) P01322, (Mouse) P01325, (Rat) P01323, (Mouse) P01326

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Entrez Gene ID: (Rat) 24505, (Mouse) 16333, (Rat) 24506, (Mouse) 16334

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Function(s)
protease binding insulin receptor binding insulin-like growth factor receptor binding hormone activity identical protein binding chaperone binding protein complex binding growth factor
Process(es)
MAPK cascade negative regulation of acute inflammatory response glucose metabolic process regulation of cellular amino acid metabolic process acute-phase response G-protein coupled receptor signaling pathway positive regulation of cell proliferation insulin receptor signaling pathway response to organic substance positive regulation of phosphatidylinositol 3-kinase signaling glucose transport regulation of transmembrane transporter activity activation of protein kinase B activity positive regulation of cellular protein metabolic process negative regulation of protein oligomerization regulation of protein localization negative regulation of NAD(P)H oxidase activity response to cytokine wound healing negative regulation of protein catabolic process glucose homeostasis positive regulation of MAPK cascade response to peptide hormone positive regulation of glycogen biosynthetic process positive regulation of DNA replication negative regulation of glycogen catabolic process positive regulation of glycolytic process positive regulation of mitotic nuclear division negative regulation of proteolysis negative regulation of fatty acid metabolic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway alpha-beta T cell activation regulation of protein secretion negative regulation of protein secretion positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation negative regulation of lipid catabolic process positive regulation of NF-kappaB transcription factor activity response to cAMP positive regulation of protein kinase B signaling fatty acid homeostasis negative regulation of respiratory burst involved in inflammatory response positive regulation of respiratory burst positive regulation of protein localization to nucleus negative regulation of feeding behavior carbohydrate metabolic process negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity ER overload response myoblast fusion biological_process lipid catabolic process regulation of protein binding positive regulation of phosphatidylinositol 3-kinase activity canonical Wnt signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress activation of JUN kinase activity regulation of gene expression myotube differentiation regulation of phosphorylation
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