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Proteintech
cyclin B1 Monoclonal Antibody (1F3G11), CoraLite® Plus 488
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FIGURE: 1 / 1
cyclin B1 Antibody (CL48867686100UL) in Flow
1X10^6 Jurkat cells were intracellularly stained with 0.4 µg CoraLite 488 Anti-Human cyclin B1 (Product # CL48867686100UL), Clone:1F3G11) (red), or 0.4 µg Mouse IgG1 Isotype Control (CL488-66360, Clone: T1F8D3F10) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL48867686100UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F3G11
Conjugate
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; OTTHUMP00000221981; OTTHUMP00000223023
Gene Aliases: Ccn-2; CCNB; CCNB1; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb-4; Cycb-5; CycB1; Cycb1-rs1
UniProt ID: (Rat) P30277, (Mouse) P24860
Entrez Gene ID: (Rat) 25203, (Mouse) 268697
oocyte maturation
in utero embryonic development
negative regulation of protein phosphorylation
protein complex assembly
protein phosphorylation
cell cycle
mitotic spindle organization
mitotic nuclear division
mitotic metaphase plate congression
negative regulation of gene expression
positive regulation of mRNA 3'-end processing
positive regulation of histone phosphorylation
positive regulation of cell cycle
positive regulation of mitotic cell cycle
positive regulation of fibroblast proliferation
cell division
positive regulation of attachment of spindle microtubules to kinetochore
positive regulation of cardiac muscle cell proliferation
regulation of chromosome condensation
regulation of mitotic cell cycle spindle assembly checkpoint
histone H3-S10 phosphorylation involved in chromosome condensation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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