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BCLAF1 Monoclonal Antibody (1D6G7), CoraLite® Plus 488
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FIGURE: 1 / 1
BCLAF1 Antibody (CL48867860100UL) in Flow
1X10^6 HepG2 cells were intracellularly stained with 0.4 µg CoraLite 488 Anti-Human BCLAF1 (Product # CL48867860100UL), Clone:1D6G7) (red), or 0.4 µg Mouse IgG1 Isotype Control (CL488-66360, Clone: T1F8D3F10) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL48867860100UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1D6G7
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
BCLAF1 is an intracellular, death promoting transcriptional repressor of survival genes that interacts with several members of the BCL2 family of proteins. It shows homology to the basic leucine zipper (bzip) and MYB DNA binding domains.From recent research it can be concluded that in case of apoptotic cells this protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope. When over expressed this protein induces apoptosis and can be suppressed by co-expression of BCL2 proteins. Also known as BTF, it triggers a proapoptotic signal, potentially helpful to overcome the resistance to STI571.BCLAF1 is found to express mostly in skeletal muscles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bcl-2-associated transcription factor 1; BCLAF1 and THRAP3 family member 1; BP-1; Btf; Btf-s; KIAA0164; unnamed protein product
Gene Aliases: 2610102K23Rik; 2700025J07Rik; 2810454G14Rik; 5730534O06Rik; Aa2-041; AI450190; AW556225; BCLAF1; bK211L9.1; BTF; KIAA0164; mKIAA0164
UniProt ID: (Human) Q9NYF8, (Mouse) Q8K019
Entrez Gene ID: (Human) 9774, (Mouse) 72567, (Rat) 293017
apoptotic process
cellular response to DNA damage stimulus
positive regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cellular response to leukemia inhibitory factor
positive regulation of DNA-templated transcription, initiation
positive regulation of intrinsic apoptotic signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of DNA-templated transcription in response to stress
positive regulation of response to DNA damage stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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