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Proteintech
DNM2 Monoclonal Antibody (1B8H3), CoraLite® 555
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Product Details
CL555-68209
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B8H3
Immunogen
DNM2 fusion protein Ag6274
Conjugate
Excitation/Emission Max
555/570 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: RRGWLTINNI SLMKGGSKEY WFVLTAESLS WYKDEEEKEK KYMLPLDNLK IRDVEKGFMS NKHVFAIFNT EQRNVYKDLR QIELACDSQE DVDSWKASFL RAGVYPEKDQ AENEDGAQEN TFSMDPQLER QVETIRNLVD SYVAIINKSI RDLMPKTIMH LMINNTKAFI HHELLAYLYS SADQSSLMEE SADQAQRRDD MLRMYHALKE ALNIIGDIST STVSTPVPPP VDDTWLQSAS SHSPTPQRRP VSSIHPPGRP PAVRGPTPGP PLIPVPVGAA ASFSAPPIPS RPGPQSVFAN SDLFPAPPQI PSRPVRIPPG IPPGVPSRRP PAAPSRPTII RPAEPSLLD
Target Information
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dynamin 2; Dynamin II; Dynamin UDNM; Dynamin-2; unnamed protein product
Gene Aliases: b2b2159Clo; CMT2M; CMTDI1; CMTDIB; DI-CMTB; DNM2; DYIIAAB; DYN2; DYNII; LCCS5; Udnm
UniProt ID: (Human) P50570, (Rat) P39052, (Mouse) P39054
Entrez Gene ID: (Rabbit) 100348451, (Human) 1785, (Pig) 100622538, (Rat) 25751, (Mouse) 13430
nucleotide binding
GTPase activity
protein binding
GTP binding
phosphatidylinositol-4,5-bisphosphate binding
microtubule binding
hydrolase activity
SH3 domain binding
enzyme binding
protein kinase binding
D2 dopamine receptor binding
protein complex binding
phosphatidylinositol 3-kinase regulatory subunit binding
WW domain binding
nitric-oxide synthase binding
membrane traffic protein
G2/M transition of mitotic cell cycle
regulation of transcription, DNA-templated
post-Golgi vesicle-mediated transport
endocytosis
receptor-mediated endocytosis
phagocytosis
autophagy
centrosome cycle
signal transduction
synaptic vesicle budding from presynaptic endocytic zone membrane
antigen processing and presentation of exogenous peptide antigen via MHC class II
regulation of axon extension
receptor internalization
transferrin transport
positive regulation of apoptotic process
stress fiber assembly
positive regulation of transcription, DNA-templated
synaptic vesicle transport
neuron projection morphogenesis
protein polymerization
membrane organization
actin filament bundle organization
membrane tubulation
vesicle scission
negative regulation of membrane tubulation
G-protein coupled receptor internalization
Golgi to plasma membrane transport
spermatogenesis
metabolic process
response to light stimulus
positive regulation of lamellipodium assembly
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of Rac protein signal transduction
response to cocaine
macropinocytosis
positive regulation of nitric oxide biosynthetic process
positive regulation of endocytosis
positive regulation of phagocytosis
cilium morphogenesis
cellular response to carbon monoxide
cellular response to X-ray
cellular response to nitric oxide
positive regulation of substrate adhesion-dependent cell spreading
cellular response to dopamine
regulation of Golgi organization
positive regulation of sodium:potassium-exchanging ATPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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