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Proteintech
UBE2C Monoclonal Antibody (1C12H8), CoraLite® 594
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Product Details
CL594-66087
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C12H8
Immunogen
UBE2C fusion protein Ag19235
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MASQNRDPA ATSVAAARKG AEPSGGAARG PVGKRLQQEL MTLMMSGDKG ISAFPESDNL FKWVGTIHGA AGTVYEDLRY KLSLEFPSGY PYNAPTVKFL TPCYHPNVDT QGNICLDILK EKWSALYDVR TILLSIQSLL GEPNIDSPLN THAAELWKNP TAFKKYLQET YSKQVTSQEP
Target Information
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (E3-independent) E2 ubiquitin-conjugating enzyme C; cyclin-selective ubiquitin carrier protein; E2 ubiquitin-conjugating enzyme C; mitotic-specific ubiquitin-conjugating enzyme; RP3-447F3.1; UbcH10; UBE2C; Ubiquitin carrier protein C; ubiquitin conjugating enzyme E2C; Ubiquitin-conjugating enzyme E2 C; Ubiquitin-protein ligase C; unnamed protein product
Gene Aliases: 1110015A16Rik; D2Ertd695e; dJ447F3.2; UBCH10; UBE2C
UniProt ID: (Human) O00762, (Mouse) Q9D1C1
Entrez Gene ID: (Human) 11065, (Rat) 296368, (Mouse) 68612
nucleotide binding
ubiquitin-protein transferase activity
protein binding
ATP binding
transferase activity
ubiquitin-like protein transferase activity
ubiquitin-like protein ligase binding
ubiquitin protein ligase activity
ubiquitin conjugating enzyme activity
ligase activity
ubiquitin protein ligase binding
ubiquitin-protein ligase
protein polyubiquitination
ubiquitin-dependent protein catabolic process
exit from mitosis
free ubiquitin chain polymerization
protein ubiquitination
regulation of mitotic metaphase/anaphase transition
anaphase-promoting complex-dependent catabolic process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of exit from mitosis
protein modification by small protein conjugation
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of mitotic metaphase/anaphase transition
cell division
protein K48-linked ubiquitination
protein K11-linked ubiquitination
positive regulation of ubiquitin protein ligase activity
negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
cell cycle
mitotic nuclear division
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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