Search
Proteintech
ARG1 Monoclonal Antibody (5D6D12), CoraLite® 594
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL594-66129
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5D6D12
Immunogen
Full length Arginase 1 protein.
Conjugate
CoraLite® 594
CoraLite® 594
CoraLite® 594
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1.67 mg/mL
Amount
167 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A-I; AI type I arginase; Arg1; Arginase; arginase (EC 3.5.3.1); arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; HGNC:663; Liver Arginase; liver arginase (E.C. 3.5.3.1); liver-type arginase; Type 1 Arginase; type I arginase; unnamed protein product
Gene Aliases: AI; Arg-1; PGIF
UniProt ID: (Pig) Q95JC8, (Human) P05089, (Mouse) Q61176, (Rat) P07824
Entrez Gene ID: (Pig) 397115, (Human) 383, (Mouse) 11846, (Rat) 29221
urea cycle
defense response to protozoan
negative regulation of activated T cell proliferation
negative regulation of interferon-gamma-mediated signaling pathway
positive regulation of neutrophil mediated killing of fungus
negative regulation of T-helper 2 cell cytokine production
arginine metabolic process
arginine catabolic process
regulation of cell proliferation
negative regulation of T cell proliferation
neutrophil mediated killing of fungus
positive regulation of endothelial cell proliferation
response to nematode
response to selenium ion
collagen biosynthetic process
regulation of L-arginine import across plasma membrane
liver development
female pregnancy
response to xenobiotic stimulus
response to herbicide
response to manganese ion
response to zinc ion
response to amine
lung development
response to lipopolysaccharide
response to vitamin A
response to vitamin E
response to amino acid
response to peptide hormone
response to cadmium ion
response to steroid hormone
response to axon injury
response to methylmercury
mammary gland involution
maternal process involved in female pregnancy
cellular response to hydrogen peroxide
cellular response to lipopolysaccharide
cellular response to interleukin-4
cellular response to glucagon stimulus
cellular response to dexamethasone stimulus
cellular response to transforming growth factor beta stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support