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PD-1/CD279 Monoclonal Antibody (4H4D1), CoraLite® 594
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FIGURE: 1 / 2
PD-1/CD279 Antibody (CL594-66220) in IHC (PFA)
Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded human angioimmunoblastic T-cell lymphoma tissue using CoraLite®594 PD-1/CD279 antibody (CL594-66220, Clone: 4H4D1) at dilution of 1:200. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
CL594-66220
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
4H4D1
Immunogen
PD-1/CD279 fusion protein Ag12470
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MQIPQAPWP VVWAVLQLGW RPGWFLDSPD RPWNPPTFSP ALLVVTEGDN ATFTCSFSNT SESFVLNWYR MSPSNQTDKL AAFPEDRSQP GQDCRFRVTQ LPNGRDFHMS VVRARRNDSG TYLCGAISLA PKAQIKESLR AELRVTERRA EVPTAHPSPS PRPAGQFQTL VVGVVGGLLG SLVLLVWVLA VICSRAARGT IGARRTGQPL KEDPSAVPVF SVDYGELDFQ WREKTPEPPV PCVPEQTEYA TIVFPSGMGT SSPARRGSAD GPRSAQPLRP EDGHCSWPL
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD279; CD279; PD-1; hPD1; mPD-1; PD-1; PD1; alternatively spliced; PDCD1; programmed cell death 1 protein; Programmed cell death protein 1; programmed cell death protein 1-like; Protein PD-1; Protein PD1; sCD279; soluble CD279; systemic lupus erythematosus susceptibility 2; unnamed protein product
Gene Aliases: AIMTBS; CD279; hPD-1; hPD-l; hSLE1; Ly101; PD-1; PD1; Pdc1; PDCD1; SLEB2
UniProt ID: (Human) Q15116, (Mouse) Q02242
Entrez Gene ID: (Human) 5133, (Rat) 301626, (Mouse) 18566
negative regulation of tolerance induction
biological_process
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of T cell apoptotic process
immune system process
apoptotic process
B cell apoptotic process
adaptive immune response
negative regulation of T cell mediated immune response to tumor cell
negative regulation of B cell apoptotic process
humoral immune response
regulation of immune response
negative regulation of immune response
negative regulation of T cell activation
negative regulation of multicellular organismal process
regulatory T cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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