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Proteintech
ACTN4 Monoclonal Antibody (1E12B8), CoraLite® 594
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Product Details
CL594-66628
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E12B8
Immunogen
ACTN4 fusion protein Ag13549
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: TTVTPQIIN SKWEKVQQLV PKRDHALLEE QSKQQSNEHL RRQFASQANV VGPWIQTKME EIGRISIEMN GTLEDQLSHL KQYERSIVDY KPNLDLLEQQ HQLIQEALIF DNKHTNYTME HIRVGWEQLL TTIARTINEV ENQILTRDAK GISQEQMQEF RASFNHFDKD HGGALGPEEF KACLISLGYD VENDRQGEAE FNRIMSLVDP NHSGLVTFQA FIDFMSRETT DTDTADQVIA SFKVLAGDKN FITAEELRRE LPPDQAEYCI ARMAPYQGPD AVPGALDYKS FSTALYGESD L
Target Information
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actinin-Alpha-4; alpha actinin 4; Alpha-actinin-4; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; Non-muscle alpha-actinin 4; transcriptional coactivator; unnamed protein product
Gene Aliases: ACTININ-4; ACTN4; C77391; FSGS; FSGS1
UniProt ID: (Human) O43707, (Mouse) P57780, (Rat) Q9QXQ0
Entrez Gene ID: (Human) 81, (Mouse) 60595, (Rat) 63836
RNA polymerase II regulatory region sequence-specific DNA binding
nucleoside binding
transcription coactivator activity
RNA binding
actin binding
integrin binding
calcium ion binding
protein binding
ligand-dependent nuclear receptor binding
chromatin DNA binding
identical protein binding
protein homodimerization activity
retinoic acid receptor binding
ion channel binding
metal ion binding
actin filament binding
ligand-dependent nuclear receptor transcription coactivator activity
protein complex binding
nuclear hormone receptor binding
poly(A) RNA binding
protein N-terminus binding
transport
protein transport
peroxisome proliferator activated receptor signaling pathway
regulation of apoptotic process
retinoic acid receptor signaling pathway
positive regulation of pinocytosis
actin filament bundle assembly
negative regulation of cellular component movement
positive regulation of cellular component movement
bicellular tight junction assembly
protein localization to bicellular tight junction
regulation of nucleic acid-templated transcription
response to hypoxia
actin cytoskeleton organization
vesicle transport along actin filament
positive regulation of cell migration
positive regulation of sodium:proton antiporter activity
tumor necrosis factor-mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
muscle cell development
negative regulation of substrate adhesion-dependent cell spreading
positive regulation of NIK/NF-kappaB signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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