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Proteintech
C5 Monoclonal Antibody (2G8C9), CoraLite® 594
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Product Details
CL594-66634
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2G8C9
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: GSSHAVMDIS LPTGISANEE DLKALVEGVD QLFTDYQIKD GHVILQLNSI PSSDFLCVRF RIFELFEVGF LSPATFTVYE YHRPDKQCTM FYSTSNIKIQ KVCEGAACKC VEADCGQMQE ELDLTISAET RKQTACKPEI AYAYKVSITS ITVENVFVKY KATLLDIYKT GEAVAEKDSE ITFIKKVTCT NAELVKGRQY LIMGKEALQI KYNFSFRYIY PLDSLTWIEY WPRDTTCSSC QAFLANLDEF AEDIFLNGC
Target Information
C5 (Complement C5) is a Protein Coding gene. Diseases associated with C5 include Complement Component 5 Deficiency and Eculizumab, Poor Response To. Among its related pathways are GPCR downstream signalling and Acquired partial lipodystrophy / Barraquer-Simons syndrome. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and endopeptidase inhibitor activity. An important paralog of this gene is C3. This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anaphylatoxin C5; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a anaphylatoxin; Complement C5; Complement Component 5; CPAMD4; prepro-C5
Gene Aliases: C5; C5a; C5b; C5D; CPAMD4; ECLZB
UniProt ID: (Human) P01031
Entrez Gene ID: (Human) 727
complement activation, lectin pathway
immune system process
regulation of immune system process
chemotaxis
inflammatory response
complement activation
complement activation, alternative pathway
complement activation, classical pathway
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of vascular endothelial growth factor production
negative regulation of macrophage chemotaxis
cell migration
leukocyte chemotaxis
killing of cells of other organism
positive regulation of chemokine production
innate immune response
regulation of chemotaxis
cell chemotaxis
complement activation, GZMK pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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