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Proteintech
SOCS3 Monoclonal Antibody (1G2B12), CoraLite® 594
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Product Details
CL594-66797
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G2B12
Immunogen
SOCS3 fusion protein Ag5386
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MVTHSKFPA AGMSRPLDTS LRLKTFSSKS EYQLVVNAVR KLQESGFYWS AVTGGEANLL LSAEPAGTFL IRDSSDQRHF FTLSVKTQSG TKNLRIQCEG GSFSLQSDPR STQPVPRFDC VLKLVHHYMP PPGAPSFPSP PTEPSSEVPE QPSAQPLPGS PPRRAYYIYS GGEKIPLVLS RPLSSNVATL QHLCRKTVNG HLDSYEKVTQ LPGPIREFLD QYDAPL
Target Information
Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CIS-3; cytokine inducible SH2-containing protein 3; Cytokine-inducible SH2 protein 3; E2a-Pbx1 target gene in fibroblasts 10; MGC71791; Protein EF-10; SOCS-3; SOCS3; SSI-3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3; unnamed protein product
Gene Aliases: ATOD4; CIS3; Cish3; EF-10; Ef10; SOCS-3; SOCS3; SSI-3; SSI3
UniProt ID: (Human) O14543, (Mouse) O35718
Entrez Gene ID: (Human) 9021, (Mouse) 12702
signal transduction
JAK-STAT cascade
negative regulation of signal transduction
protein ubiquitination
cytokine-mediated signaling pathway
cell differentiation
intracellular signal transduction
negative regulation of apoptotic process
positive regulation of cell differentiation
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
branching involved in labyrinthine layer morphogenesis
placenta blood vessel development
interleukin-6-mediated signaling pathway
T-helper 17 cell lineage commitment
cellular response to interleukin-17
cellular response to leukemia inhibitory factor
regulation of protein phosphorylation
negative regulation of protein kinase activity
regulation of growth
regulation of cell differentiation
trophoblast giant cell differentiation
spongiotrophoblast differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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